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Merck
CN

N5785

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate

meets USP testing specifications

Synonym(s):

L-(−)-Noradrenaline (+)-bitartrate salt monohydrate

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About This Item

Empirical Formula (Hill Notation):
C8H11NO3 · C4H6O6 · H2O
CAS Number:
108341-18-0
Molecular Weight:
337.28
NACRES:
NA.21
PubChem Substance ID:
24897754
UNSPSC Code:
51391722
MDL number:
MFCD00150449

Key Documents

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Product Name

L-(−)-Norepinephrine (+)-bitartrate salt monohydrate, meets USP testing specifications

InChI

1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1

SMILES string

O.O[C@H]([C@@H](O)C(O)=O)C(O)=O.NC[C@H](O)c1ccc(O)c(O)c1

InChI key

LNBCGLZYLJMGKP-LUDZCAPTSA-N

agency

USP/NF
meets USP testing specifications

form

solid

application(s)

pharmaceutical (small molecule)

Quality Level

200

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Related Categories

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000493699
0000493699
0000458473
0000458472
0000458472

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Megan D Montgomery et al.
PloS one, 12(1), e0168409-e0168409 (2017-01-13)
Alpha-1 adrenergic receptors mediate adaptive effects in the heart and cardiac myocytes, and a myocyte survival pathway involving the alpha-1A receptor subtype and ERK activation exists in vitro. However, data in vivo are limited. Here we tested A61603 (N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide), a
Nur Zeynep Gungor et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(10), 2126-2133 (2018-04-29)
The bed nucleus of the stria terminalis (BNST) regulates defensive responses to threats and its anteroventral portion (BNST-AV) is involved. BNST-AV contains a minority of glutamatergic neurons scattered among a dominant population of GABAergic cells. There is evidence that these
Brian C Jensen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 382(5-6), 475-482 (2010-09-22)
Alpha-1-adrenergic receptors (α1-ARs) regulate coronary arterial blood flow by binding catecholamines, norepinephrine (NE), and epinephrine (EPI), causing vasoconstriction when the endothelium is disrupted. Among the three α1-AR subtypes (α1A, α1B, and α1D), the α1D subtype predominates in human epicardial coronary
Asuka Inoue et al.
Cell, 177(7), 1933-1947 (2019-06-05)
Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence selectivity determinants remain elusive. Here
Pooja R Patel et al.
Journal of bioanalysis & biomedicine, 7(3), 75-80 (2015-07-15)
To determine the role of norepinephrine (NE) on DNA damage and reactive oxygen species (ROS) generation in ovarian surface epithelial cells. Non-tumorigenic, immortalized ovarian surface epithelial cells were treated with NE, bleomycin, and bleomycin followed by NE. The comet assay
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