N0392
Nordoxepin hydrochloride
analytical standard, ≥98.0% (TLC), powder
Synonym(s):
11(6H)-(3-[Methylamino]propylidene)dibenz[b,e]oxepine
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About This Item
Empirical Formula (Hill Notation):
C18H19NO · HCl
CAS Number:
Molecular Weight:
301.81
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;
SMILES string
Cl.CNCC\C=C1/c2ccccc2COc3ccccc13
InChI key
GNPPEZGJRSOKRE-QFHYWFJHSA-N
grade
analytical standard
assay
≥98.0% (TLC)
form
powder
technique(s)
HPLC: suitable
color
white to yellow
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
Related Categories
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Doxepin metabolite.
Features and Benefits
Shelf-life of the powder is at least 10 years.
Other Notes
Mixture of cis- and trans-isomers
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
Antonia Gronewold et al.
Forensic science international, 190(1-3), 74-79 (2009-06-16)
Body fluids and tissues in eight doxepin (Dox)-related deaths were investigated in order to prove whether the individual concentration of Dox, the concentration sum of parent drug and its active metabolite N-desmethyldoxepin (NDox) or the concentration ratio Dox/Ndox valuably contribute
Anna Koski et al.
The American journal of forensic medicine and pathology, 28(3), 259-261 (2007-08-28)
It has been suggested that the polymorphism of the CYP2D6 gene can contribute to occurrence of fatal adverse effects. We therefore investigated postmortem toxicology cases of fatal drug poisonings related to CYP2D6 substrates, with the manner of death denoted as
M Adamczyk et al.
Therapeutic drug monitoring, 17(4), 371-376 (1995-08-01)
A high-performance liquid chromatographic (HPLC) method was developed for the quantitative, simultaneous determination of the following four compounds in serum: E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin. A 3-microns analytical silica column (6 x 100 mm) was employed with the mobile phase
Sebastian Härtter et al.
Pharmaceutical research, 19(7), 1034-1037 (2002-08-16)
This study was conducted to identify the cytochrome P450s (CYPs) responsible for the metabolism of the cis- and trans-isomers of the tricyclic antidepressant doxepin to its pharmacologically active N-desmethylmetabolite by in vitro techniques. The doxepin N-demethylation was studied by means
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