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M8277

Supelco

Midodrine hydrochloride

analytical standard, for drug analysis

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Synonym(s):
(±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol
Empirical Formula (Hill Notation):
C12H18N2O4 · HCl
CAS Number:
3092-17-9
Molecular Weight:
290.74
MDL number:
MFCD00079455
UNSPSC Code:
41116107
PubChem Substance ID:
329818055
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Stability indicating RP-HPLC assay method for estimation of midodrine hydrochloride in bulk and tablets
Jain.KH, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 9(9), 283-287 (2016)
D B Barber et al.
Spinal cord, 38(2), 109-111 (2000-04-13)
A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions. To discuss the use of midodrine hydrochloride for the treatment of orthostatic hypotension in early tetraplegia. Department of Rehabilitation Medicine, The University
Horacio Kaufmann et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 22(2), 79-90 (2011-11-03)
There is no widely accepted validated scale to assess the comprehensive symptom burden and severity of neurogenic orthostatic hypotension (NOH). The Orthostatic Hypotension Questionnaire (OHQ) was developed, with two components: the six-item symptoms assessment scale and a four-item daily activity
Ying Liao et al.
The American journal of cardiology, 112(6), 816-820 (2013-06-06)
This study was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS). One hundred and eight children diagnosed with POTS and 20
Douglas Z Liou et al.
Chest, 144(3), 1055-1057 (2013-09-07)
Thoracic duct injury is a rare but serious complication following surgery of the neck or chest that leads to uncontrolled chyle leak. Conventional management includes drainage, nutritional modification, or aggressive surgical interventions such as thoracic duct ligation, flap coverage, fibrin
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