Skip to Content
Merck
CN

M8277

Midodrine hydrochloride

analytical standard, for drug analysis

Synonym(s):

(±)-1-(2,5-Dimethoxyphenyl)-2-glycinamidoethanol

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C12H18N2O4 · HCl
CAS Number:
3092-17-9
Molecular Weight:
290.74
NACRES:
NA.24
PubChem Substance ID:
329818055
UNSPSC Code:
41116107
MDL number:
MFCD00079455

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

MGCQZNBCJBRZDT-UHFFFAOYSA-N

SMILES string

Cl.COc1ccc(OC)c(c1)C(O)CNC(=O)CN

InChI

1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Midodrine is a prodrug and a long acting α-adrenergic stimulating agent, and forms an active metabolite, desglymidodrine, which causes an elevation of the systemic blood pressure with the reduction in heart rate.

Application

Midodrine hydrochloride may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

α-Adrenergic agonist; vasoconstrictor

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

监管及禁止进口产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCF0296
BCCD3381
BCBW4710
BCBT9587
BCBR4789

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Amanda J Ross et al.
Clinical science (London, England : 1979), 126(4), 289-296 (2013-08-28)
POTS (postural tachycardia syndrome) is a chronic form of OI (orthostatic intolerance). Neuropathic POTS is characterized by decreased adrenergic vasoconstriction, whereas hyperadrenergic POTS exhibits increased adrenergic vasoconstriction. We hypothesized that midodrine, an α1-adrenergic receptor agonist, would increase CVR (calf vascular
Determination of midodrine in human plasma by high-performance liquid chromatography with fluorescence detection
Yoshida H, et al.
Analytical Sciences, 19(2), 317-319 (2003)
Jacobus J C M Romme et al.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 13(11), 1639-1647 (2011-07-15)
Initial treatment of vasovagal syncope (VVS) consists of advising adequate fluid and salt intake, regular exercise, and physical counterpressure manoeuvres. Despite this treatment, up to 30% of patients continue to experience regular episodes of VVS. We investigated whether additional Midodrine
J M Soler et al.
European journal of physical and rehabilitation medicine, 47(4), 677-681 (2012-01-10)
Spinal cord injury (SCI) is associated with impaired ejaculation. After SCI, more stimuli may be required to trigger what remains of sexual reflexes. Penile vibratory stimulation (PVS) induces a strong afferent nerve stimulation and intense activation of the autonomic nervous
D B Barber et al.
Spinal cord, 38(2), 109-111 (2000-04-13)
A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions. To discuss the use of midodrine hydrochloride for the treatment of orthostatic hypotension in early tetraplegia. Department of Rehabilitation Medicine, The University
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service