Skip to Content
Merck
CN

M4627

1-Methylnicotinamide chloride

analytical standard

Synonym(s):

N-Methylnicotinic acid amide chloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
C7H9N2OCl
CAS Number:
1005-24-9
Molecular Weight:
172.61
NACRES:
NA.24
PubChem Substance ID:
329817903
UNSPSC Code:
41116107
MDL number:
MFCD00060042

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

SMILES string

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

grade

analytical standard

assay

≥97.5%

form

powder

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Application

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Urinary excretion product of niacin metabolism

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000483819
0000483819
0000369166
0000369166
SLCR0536

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Robert Nowak et al.
European journal of pharmacology, 640(1-3), 102-111 (2010-05-08)
The aim of the study was to examine the effect of 1-methylnicotinamide (MNA) and 1-methyl-3-nitropyridine (MNP) on mitochondria activity and proliferation of endothelial EA.hy926 cells. The activity of MNA was also referred to nicotinamide (NAM) being MNA metabolic precursor. NAM
Shi-Sheng Zhou et al.
World journal of gastroenterology, 15(45), 5674-5684 (2009-12-05)
To investigate whether nicotinamide overload plays a role in type 2 diabetes. Nicotinamide metabolic patterns of 14 diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N(1)-methylnicotinamide on glucose metabolism, plasma H(2)O(2) levels and tissue
M N Khodosovskiĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(4), 11-13 (2010-05-22)
We have studied the effect of 1-methylnicotinamide (MNA) on prooxidant - antioxidant balance parameters by measuring the concentrations of lipid peroxidation products (conjugated dienes (CD) and Schiff bases (SB)) and antioxidant system factors (alpha-tocoferol (alpha-T), retinol (Ret) in the blood
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 27(5), 543-547 (2012-03-29)
Aldehyde oxidase (AO) plays a role in metabolizing many drugs, such as methotrexate and 6-mercaptopurine. We previously showed that AO activity in rat liver rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated at the protein
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service