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M0600900

Metamizole sodium

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dipyrone monohydrate

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About This Item

Empirical Formula (Hill Notation):
C13H16N3NaO4S · H2O
CAS Number:
5907-38-0
Molecular Weight:
351.35
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

metamizole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C13H17N3O4S.Na.H2O/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;;/h4-8H,9H2,1-3H3,(H,18,19,20);;1H2/q;+1;/p-1

InChI key

UNZIDPIPYUMVPA-UHFFFAOYSA-M

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metamizole sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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M0600905

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PHR2783

Metamizole Impurity A, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100 mg

PHR2784

Metamizole Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100 mg

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Metamizole Impurity C, certified reference material, pharmaceutical secondary standard

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Metamizole Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100 mg

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

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Update on the incidence of metamizole sodium-induced blood dyscrasias in Poland.
Basak G W, et al.
The Journal of International Medical Research, 38(4), 1374-1380 (2010)
C G Manole et al.
Journal of cellular and molecular medicine, 15(11), 2284-2296 (2011-09-08)
We used rat experimental myocardial infarction to study the ultrastructural recovery, especially neo-angiogenesis in the infarction border zone. We were interested in the possible role(s) of telocytes (TCs), a novel type of interstitial cell very recently discovered in myocardim (see
E Marciniak et al.
Domestic animal endocrinology, 58, 97-103 (2016-10-30)
This study tested the hypothesis that salsolinol, a derivative of dopamine, affects GnRH and LH secretion in lactating sheep. In the in vivo experiment, the structural analogue of salsolinol, 1-methyl-3,4-dihydroisoquinoline (1-MeDIQ), was infused into the infundibular nucleus-median eminence of sheep at
Acute kidney injury associated with metamizole sodium ingestion.
Hassan K, et al.
Renal Failure, 33(5), 544-547 (2011)
Berenice Ovalle-Magallanes et al.
The Journal of pharmacy and pharmacology, 67(12), 1733-1743 (2015-09-27)
This work was undertaken to assess the antinociceptive and hypoglycaemic properties of a quantified extract of Conyza filaginoides (CFOE), as well as the antinociceptive potential of rutin, the main active compound of the plant, in normoglycaemic and/or hyperglycaemic mice (nicotinamide-streptozotocin
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