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About This Item
Linear Formula:
CH2[P(O)(OH)2]2
CAS Number:
Molecular Weight:
176.00
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1708494
InChI
1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
SMILES string
OP(O)(=O)CP(O)(O)=O
InChI key
MBKDYNNUVRNNRF-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
medronic acid
manufacturer/tradename
EDQM
mp
197-199 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Medronic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hao Shen et al.
Journal of clinical microbiology, 53(3), 777-781 (2014-12-19)
Prosthetic joint infection (PJI) is a rare but refractory complication of arthroplasty. Accurate identification of pathogens is a key step for successful treatment of PJI, which remains a challenge for clinicians and laboratory workers. We designed a combined culture method
Ewa Matczak-Jon et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 11(8), 2357-2372 (2005-01-26)
The crystal structures of 3-methylpiperid-1-ylmethane-1,1-diphosphonic (2), 4-methylpiperid-1-ylmethane-1,1-diphosphonic (3), 2-ethylpiperid-1-ylmethane-1,1-diphosphonic (4), and 2-methylpiperid-1-ylmethane-1,1-diphosphonic (5) acids have been determined and are discussed with respect to their molecular organization and crystal-packing preferences. The chair conformation, predominant also in solution, favors equatorial positioning of
Domenick A Prosdocimo et al.
American journal of physiology. Cell physiology, 296(4), C828-C839 (2009-02-06)
Extracellular inorganic pyrophosphate (PP(i)) is a potent suppressor of physiological calcification in bone and pathological calcification in blood vessels. Ectonucleotide pyrophosphatase/phosphodiesterases (eNPPs) generate PP(i) via the hydrolysis of ATP released into extracellular compartments by poorly understood mechanisms. Here we report
J C Frith et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 12(9), 1358-1367 (1997-09-01)
Clodronate, alendronate, and other bisphosphonates are widely used in the treatment of bone diseases characterized by excessive osteoclastic bone resorption. The exact mechanisms of action of bisphosphonates have not been identified but may involve a toxic effect on mature osteoclasts
Makbule Asikoglu et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(9), 1616-1621 (2009-05-22)
The aim of the present study was to label a therapeutic dose of zoledronic acid (ZOL) with Tc-99m, evaluate its in vitro stability and compare its biodistribution to (99m)Tc-methylene biphosphonate ((99m)Tc-MDP) in normal rabbits. Preparation of 0.50 mg of (99m)Tc-ZOL
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