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L5750

Sigma-Aldrich

Sodium dodecyl sulfate

92.5-100.5% based on total alkyl sulfate content basis

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Synonym(s):
Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate
Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
151-21-3
Molecular Weight:
288.38
Beilstein:
3599286
EC Number:
205-788-1
MDL number:
MFCD00036175
UNSPSC Code:
12161900
eCl@ss:
39093306
PubChem Substance ID:
24896412
NACRES:
NA.21

description

anionic

Quality Level

200

Assay

92.5-100.5% based on total alkyl sulfate content basis

mol wt

288.38 g/mol

aggregation number

62

CMC

7-10 mM (20-25°C)

mp

204-207 °C (lit.)

transition temp

cloud point >100 °C

solubility

water: soluble

HLB

40

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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Application

Sodium dodecyl sulfate has been used:
  • to dissolve insoluble purple formazan in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay
  • to perform SDS–PAGE of yeast tubulin
  • as an additive in linolenic acid solution to assess the total antioxidative activity (TAA) of the bacteria using the linolenic acid test (LA-test)

Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS)/lauryl sulfate, an ionic detergent has the ability to distract biological membranes. It can block RNase and deoxyribonuclease (DNase) activity. SDS is one of the main constituents of several reagents, that are used to purify nucleic acids. It is also considered as a permeability enhancer in oral formulations.

Quality

Predominantly (approx. 70%) C12; lauryl sulfate, sodium salt; balance consists of higher homologs.

Analysis Note

Actual composition given on label

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H315,H318,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Resilient Ribonucleases
RNA Methodologies (2010)
The two alpha-tubulin isotypes in budding yeast have opposing effects on microtubule dynamics in vitro
Bode CJ, et al.
EMBO Reports, 4(1), 94-99 (2003)
Safety and efficacy of self-assembling bubble carriers stabilized with sodium dodecyl sulfate for oral delivery of therapeutic proteins
Lin P Y, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 259, 168-175 (2017)
Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes.
Fontanay S, et al.
Journal of Ethnopharmacology, 120(2), 272-276 (2008)
Two antioxidative lactobacilli strains as promising probiotics
Kullisaar T, et al.
International Journal of Food Microbiology, 72(3), 215-224 (2002)
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