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L0750000

Loperamide hydrochloride

Name: Loperamide hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₃ClN₂O₂ · HCl

CAS Number:

34552-83-5

Molecular Weight:

513.50

MDL number:

MFCD00058581

UNSPSC Code:

41116107

PubChem Substance ID:

329817374

NACRES:

NA.24

grade

pharmaceutical primary standard

Agency

EP Reference Standard

API family

loperamide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4

InChI

1S/C29H33ClN2O2.ClH/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23;/h3-16,34H,17-22H2,1-2H3;1H

InChI key

PGYPOBZJRVSMDS-UHFFFAOYSA-N

Gene Information

human ... OPRM1(4988)

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Related Categories

Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Loperamide hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1370000

Loperamide hydrochloride, United States Pharmacopeia (USP) Reference Standard

Y0000341

Loperamide oxide monohydrate, European Pharmacopoeia (EP) Reference Standard

1370065

PHR2916

Pictograms

GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

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Lot/Batch Number

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Effect of colic vein ligature in rats with loperamide-induced constipation.

Flavia Neri et al.

Journal of biomedicine & biotechnology, 2012, 896162-896162 (2012-06-01)

Medical treatment in chronic constipation is not always successful. Surgery is indicated in unresponsive selected severe cases. This study presents the distal venous colic ligation in rat as a novel surgical approach. 16 rats (study group) were evaluated in 3

Garcinia buchananii bark extract is an effective anti-diarrheal remedy for lactose-induced diarrhea.

Paul A Boakye et al.

Journal of ethnopharmacology, 142(2), 539-547 (2012-05-31)

The extract from the stem bark of Garcinia buchananii trees is used as an anti-diarrhea remedy in sub-Saharan Africa. We tested the hypothesis that G. buchananii bark extract and its anti-motility fractions are effective treatments against lactose-induced diarrhea. A high-lactose

Irritable bowel syndrome--diarrhoea.

Arnold Wald

Best practice & research. Clinical gastroenterology, 26(5), 573-580 (2013-02-07)

IBS is a functional gastrointestinal disorder which has been subtyped according to bowel habits. This review presents recommendations for IBS-D which makes up about 1/3 of all patients and which is defined as IBS with loose or watery stools with

Local loperamide injection reduces mechanosensitivity of rat cutaneous, nociceptive C-fibers.

Matthias Ringkamp et al.

PloS one, 7(7), e42105-e42105 (2012-08-01)

Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain. Since little is known about loperamide effects on the responsiveness of primary

Opioid μ-receptors as new target for insulin resistance.

Kai-Chun Cheng et al.

Pharmacology & therapeutics, 139(3), 334-340 (2013-05-22)

Type-2 diabetes is one of the fastest growing public health problems worldwide resulting from both environmental and genetic factors. Activation of μ-opioid receptor (MOR) could result in reversal of the impairment of insulin-stimulated glucose disposal in genetically obese Zucker rats

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