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Indapamide

analytical standard, for drug analysis

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Synonym(s):
N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline
Empirical Formula (Hill Notation):
C16H16ClN3O3S
CAS Number:
26807-65-8
Molecular Weight:
365.83
EC Number:
248-012-7
MDL number:
MFCD00079375
UNSPSC Code:
41116107
PubChem Substance ID:
329815359
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)

InChI key

NDDAHWYSQHTHNT-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

Indapamide is a deuretic drug, belonging to the class of benzothiadiazines. It is commonly used for the treatment of hypertension. The drug acts by causing a drop in systolic, diastolic and mean blood pressure.

Application

Indapamide may be used as an internal standard for the quantification of the analyte in pharmaceutical formulations and biological samples using different analytical techniques
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361d,H362

Hazard Classifications

Lact. - Repr. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A selective HPLC method for the determination of indapamide in human whole blood: Application to a bioequivalence study in Chinese volunteers
Hang J-T, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(1), 202-205 (2006)
Alina Porfire et al.
Journal of pharmaceutical and biomedical analysis, 70, 301-309 (2012-08-14)
This paper describes the development and application of NIR-chemometric methods for active content assay and pharmaceutical characterization (granulometric analysis and flowability assessment) of indapamide powder blends for tabletting. Indapamide powder blends were prepared and their NIR spectra were recorded in
Simultaneous estimation of amlodipine besylate and indapamide in a pharmaceutical formulation by a high performance liquid chromatographic (RP-HPLC) method
Patel.BD, et al.
Scientia Pharmaceutica, 80(3), 581-590 (2012)
Susan van Dieren et al.
Diabetes research and clinical practice, 98(1), 83-90 (2012-06-09)
To asses differences in treatment effects of a fixed combination of perindopril-indapamide on major clinical outcomes in patients with type 2 diabetes across subgroups of cardiovascular risk. 11,140 participants with type 2 diabetes, from the ADVANCE trial, were randomized to
N Beckett et al.
BMJ (Clinical research ed.), 344, d7541-d7541 (2012-01-06)
To assess if very elderly people with hypertension obtain early benefit from antihypertensive treatment. One year open label active treatment extension of randomised controlled trial (Hypertension in the Very Elderly Trial (HYVET)). Hospital and general practice based centres mainly in
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