Skip to Content
Merck
CN
All Photos(1)

Documents

G4382

Supelco

(±)-Gossypol-acetic acid

analytical standard, crystalline complex consisting of equimolar quantities of gossypol and acetic acid, ~95%

Sign Into View Organizational & Contract Pricing
All Photos(1)
Empirical Formula (Hill Notation):
C30H30O8 · C2H4O2
CAS Number:
12542-36-8
Molecular Weight:
578.61
MDL number:
MFCD00058385
UNSPSC Code:
41116107
PubChem Substance ID:
329799926
NACRES:
NA.24

grade

analytical standard

Assay

~95% (HPLC)
~95%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O

InChI

1S/C30H30O8.C2H4O2/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36;1-2(3)4/h7-12,33-38H,1-6H3;1H3,(H,3,4)

InChI key

NIOHNDKHQHVLKA-UHFFFAOYSA-N

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Reported to inhibit the autolytic conversion of pepsinogen to pepsin.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Inhibition of pepsinogen activation by gossypol.
T D Tanksley et al.
The Journal of biological chemistry, 245(23), 6456-6461 (1970-12-10)
Selim Uzunoglu et al.
Toxicology mechanisms and methods, 20(8), 482-486 (2010-09-17)
This study compared the two different commercially available in vitro viability assays: XTT and Alamar blue (AB), to detect anti-proliferative effects of AT-101, a cotton plant extract, on six different human carcinoma cell lines including: prostate (PC-3 and DU-145), breast
Studies on the nature of the inhibition by gossypol of the transformation of pepsinogen to pepsin.
R C Wong et al.
The Journal of biological chemistry, 247(5), 1625-1631 (1972-03-10)
Rebecca Suk Heist et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 5(10), 1637-1643 (2010-09-03)
AT-101 is an oral, pan Bcl-2 family protein inhibitor that has demonstrated activity in small cell lung cancer (SCLC) models. A phase I/II study was conducted combining AT-101 with topotecan in relapsed and refractory SCLC. An open-labeled multicenter phase I/II
Neal Ready et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 6(4), 781-785 (2011-02-04)
AT-101 is an inhibitor of Bcl-2 family proteins including Bcl-2, Bcl-xL, Mcl-1, and Bcl-w. In vivo and in vitro studies have exhibited broad activity of AT-101, including synergy with docetaxel in non-small cell lung cancer tumor models. We conducted a
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service