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Merck
CN

F8880

Fluocinolone acetonide

analytical standard

Synonym(s):

6α,9α-Difluoro-11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 6α,9α-Difluoro-16α-hydroxyprednisolone 16,17-acetonide, 6α-Fluorotriamcinolone acetonide, Sinalar, Synandone

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About This Item

Empirical Formula (Hill Notation):
C24H30F2O6
CAS Number:
67-73-2
Molecular Weight:
452.49
NACRES:
NA.24
PubChem Substance ID:
329799775
UNSPSC Code:
41116107
EC Number:
200-668-5
MDL number:
MFCD00010525

Key Documents

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InChI

1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

InChI key

FEBLZLNTKCEFIT-VSXGLTOVSA-N

SMILES string

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

grade

analytical standard

assay

≥97.5% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

267-269 °C (lit.)

application(s)

forensics and toxicology
veterinary

format

neat

Quality Level

100

Gene Information

human ... NR3C1(2908)

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Related Categories

Application

Fluocinolone acetonide may be used as a reference standard in the analysis of fluocinolone acetonide in samples of soil via pressurized liquid extraction (PLE) and solid-phase extraction (SPE) followed by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0808
BCBW3358
BCBW0494
BCBT8105
037K1286V

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Analytical method for the determination of trace levels of steroid hormones and corticosteroids in soil, based on PLE/SPE/LC-MS/MS.
Gineys N, et al.
Analytical and Bioanalytical Chemistry, 397(6), 2295-2302 (2010)
Michael W Stewart
Current diabetes reports, 12(4), 364-375 (2012-05-15)
Diabetic retinopathy is the leading cause of blindness in working age individuals in developed countries. Most cases of diabetes related vision loss result from breakdown of the blood-retinal barrier with resultant diabetic macular edema (DME). For over 30 years, laser
Oliver Comyn et al.
Current opinion in ophthalmology, 24(3), 248-254 (2013-03-23)
Three long-acting corticosteroid implants are now available for the treatment of retinal disease, offering control of macular edema and inflammation for between 6 months and up to 3 years. This review evaluates their efficacy and side-effect profile in comparison with
Kevin D Frick et al.
Investigative ophthalmology & visual science, 53(3), 1169-1176 (2012-01-17)
To evaluate the associations between visual acuity and self-reported visual function; visual acuity and health-related quality of life (QoL) metrics; a summary measure of self-reported visual function and health-related QoL; and individual domains of self-reported visual function and health-related QoL
Yu Wang et al.
Chemistry & biology, 19(8), 972-982 (2012-08-28)
The Hedgehog signaling pathway is linked to a variety of diseases, notably a range of cancers. The first generation of drug screens identified Smoothened (Smo), a membrane protein essential for signaling, as an attractive drug target. Smo localizes to the
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