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F1427

Supelco

Florfenicol

analytical standard, for drug analysis

Synonym(s):

Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C12H14Cl2FNO4S
CAS Number:
73231-34-2
Molecular Weight:
358.21
MDL number:
MFCD00864834
UNSPSC Code:
41116107
PubChem Substance ID:
329799680
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

100

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl

InChI

1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1

InChI key

AYIRNRDRBQJXIF-NXEZZACHSA-N

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General description

Florfenicol is a broad-spectrum amphenicol antibiotic used against diseases affecting domestic and wild animals.

Application

The analytical standard can be used as follows:
  • To measure florfenicol and its main metabolite florfenicol amine in tilapia meat by solid phase extraction (SPE) and ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
  • Multi-residue analysis of three amfenicols in animal feed samples by HPLC-MS/MS method, following European Commission Decision 2002/657/EC(2)Determination of florfenicol in different animal feedstuff samples by thin layer chromatography (TLC) coupled with HPLC-UV detection
  • Residue analysis of florfenicol in broiler meat and liver samples by a reversed phase-HPLC method in combination with UV detection at 223 nm
  • Competitive indirect-chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) based quantitative analysis of florfenicol and its major metabolite florfenicol amine in chicken muscle samples, validated as per Commission Decision 2002/657/EC

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H361fd,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 1

Target Organs

Liver,Brain,Testes,Spinal cord,Blood,gallbladder

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

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Evaluation of 27 different biochars for potential sequestration of antibiotic residues in food animal production environments
Mitchell M S, et al.
Journal of Environmental Chemical Engineering, 3(1), 162-169 (2015)
Xin Yang et al.
Microbial pathogenesis, 111, 274-279 (2017-09-11)
Escherichia coli (E. coli) is one of the most relevant opportunistic pathogenic bacteria as it may cause severe morbidity and mortality in yaks (poephagus grunniens). In recent years, several kinds of antibiotics have been widely used in Tibetan areas to treat
Joren De Smet et al.
Frontiers in pharmacology, 9, 1265-1265 (2018-11-22)
Florfenicol, which is licensed for veterinary use only, proves to be a potent antimicrobial for treatment of respiratory disease. However, the subsequent exposure of the gut microbiota to florfenicol is not well described. Hence, the effect of various administration protocols
Jacob M Swift et al.
Foodborne pathogens and disease, 14(3), 160-166 (2017-01-12)
Small ruminants have been implicated in outbreaks of Escherichia coli O157:H7 at livestock exhibitions throughout the United States. Additionally, goat meat or milk may serve as a reservoir for foodborne transmission of the organism. These associations highlight the public health
Matthew A Scott et al.
PloS one, 15(1), e0227507-e0227507 (2020-01-14)
Bovine respiratory disease (BRD) is a multifactorial disease complex and the leading infectious disease in post-weaned beef cattle. Clinical manifestations of BRD are recognized in beef calves within a high-risk setting, commonly associated with weaning, shipping, and novel feeding and
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