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F0372000

Formoterol fumarate dihydrate

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate, Formoterol hemifumarate salt monohydrate
Empirical Formula (Hill Notation):
C19H24N2O4 · 0.5C4H4O4 · H2O
CAS Number:
183814-30-4
Molecular Weight:
420.46
MDL number:
MFCD11045919
UNSPSC Code:
41116107
PubChem Substance ID:
329799658
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

formoterol 

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O.O.OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc3ccc(C[C@H](C)NC[C@@H](O)c4ccc(O)c(NC=O)c4)cc3

InChI

1S/2C19H24N2O4.C4H4O4.2H2O/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8;;/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8);2*1H2/b;;2-1+;;/t2*13-,19+;;;/m00.../s1

InChI key

RATSWNOMCHFQGJ-TUYNVFRMSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Formoterol fumarate dihydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

β2-Adrenoreceptor agonist.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000339

Formoterol for impurity I identification, European Pharmacopoeia (EP) Reference Standard

Y0000340

Formoterol fumarate for system suitability, European Pharmacopoeia (EP) Reference Standard

1286107

Formoterol fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 840.91 ((C19H24N2O4)2 · C4H4O4 ·2H2O)

1042373

Formoterol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1042351

Formoterol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1286141

N-(2-Hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl](methyl)amino}ethyl)phenyl)formamide fumarate, United States Pharmacopeia (USP) Reference Standard

PHR2703

Formoterol Fumarate, certified reference material, pharmaceutical secondary standard

1286184

Formoterol Related Compound I, United States Pharmacopeia (USP) Reference Standard

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H332,H361d,H370,H373,H412

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Repr. 2 - STOT RE 2 - STOT SE 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sean R Jesinkey et al.
The Journal of pharmacology and experimental therapeutics, 351(3), 663-673 (2014-10-09)
Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atrophy. Additionally, atomoxetine, an FDA-approved norepinephrine reuptake inhibitor, was positive in a cellular assay for

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