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E3764

Supelco

Enoxacin

analytical standard

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Synonym(s):
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid
Empirical Formula (Hill Notation):
C15H17FN4O3
CAS Number:
74011-58-8
Molecular Weight:
320.32
MDL number:
MFCD00133308
UNSPSC Code:
41116107
PubChem Substance ID:
329799054

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(nc12)N3CCNCC3

InChI

1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)

InChI key

IDYZIJYBMGIQMJ-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

General description

Chemical structure: fluoroquinolone

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Hydrophilic fluorquinolone antibiotic. Substrate of NorA, an energy dependent drug efflux pump in Staphylococcus aureus. Expression of NorA is responsible for some drug resistant infections.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. In what solvent can Product E3764, Enoxacin, be reconstituted?

    This product may be reconstituted in DMSO at 8 mg/mL.

  6. What class of antibiotics does Product E3764, Enoxacin, belong to?

    Enoxacin is a broad spectrum fluoroquinolone antibiotic used in the treatment of urinary tract infections.  

  7. What working concentration has been reported for Product E3764, Enoxacin?

    Enoxacin has been used at 1 mM on cultured Calu-3 cells to inhibit transepithelial transport of ciprofloxacin, as reported in Antimicrob. Agents Chemother. 41(12), 2693-2698 (1997).

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Xuqiang Liu et al.
Biomaterials, 35(22), 5721-5730 (2014-04-29)
The aim of this study was to assess the effect of enoxacin on osteoclastogenesis and titanium particle-induced osteolysis. Wear particles liberated from the surface of prostheses are associated with aseptic prosthetic loosening. It is well established that wear particles induce
Julien Poissy et al.
Antimicrobial agents and chemotherapy, 54(11), 4765-4771 (2010-09-02)
The prevalence of extensively drug-resistant tuberculosis (XDR-TB), defined as TB that is resistant to isoniazid, rifampin, fluoroquinolones, and aminoglycosides, is rising worldwide. The extent of Mycobacterium tuberculosis resistance to fluoroquinolones depends on the mutation in the DNA gyrase, the only
Hua Zhang et al.
Scientific reports, 7(1), 14714-14714 (2017-11-09)
Antibiotics contamination in food products is of increasing concern due to their potential threat on human health. Herein solid-phase extraction based on magnetic molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry (MMIPs-SPE-iEESI-MS) was designed for the quantitative
Sonia Melo et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(11), 4394-4399 (2011-03-04)
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the posttranscriptional level and are critical for many cellular pathways. The disruption of miRNAs and their processing machineries also contributes to the development of human tumors. A common scenario
Douglas D Young et al.
Journal of the American Chemical Society, 132(23), 7976-7981 (2010-06-10)
MicroRNAs are a recently discovered new class of important endogenous regulators of gene function. Aberrant regulation of microRNAs has been linked to various human diseases, most importantly cancer. Small molecule intervention of microRNA misregulation has the potential to provide new
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