E0753
4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one
analytical standard, for drug analysis
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About This Item
Empirical Formula (Hill Notation):
C12H11NO3
CAS Number:
Molecular Weight:
217.22
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
239-713-9
MDL number:
Product Name
4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one, analytical standard, for drug analysis
InChI key
SJHPCNCNNSSLPL-NTMALXAHSA-N
InChI
1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3/b10-8-
SMILES string
CCO\C=C1/N=C(OC1=O)c2ccccc2
assay
≥90% (HPLC)
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
94-96 °C (dec.) (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
storage temp.
2-8°C
Quality Level
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Application
4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one has been used as a haptenizing agent, which can induce an inflammatory reaction in adult zebrafish intestinal tissues and this can be used as a model for gene expression studies of the two forms of inflammatory bowel disease like Crohn′s disease and ulcerative colitis.
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Biochem/physiol Actions
Oxazolone sensitizing agent
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Comparison of two chemically-induced colitis-models in adult zebrafish, using optical projection tomography and novel transcriptional markers
Haarder S, et al.
The Open Immunology Journal, 6, 154-154 (2016)
Amalie W Arildsen et al.
Frontiers in immunology, 12, 650621-650621 (2021-04-06)
Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear. Here we colonized germ-free mice at birth or at one or eight week-of-age to
Ann Laigaard et al.
Scientific reports, 10(1), 21204-21204 (2020-12-05)
Atopic dermatitis is a chronic eczema commonly observed among children in Western countries. The gut microbiota is a significant factor in the pathogenesis, and ways to promote intestinal colonizers with anti-inflammatory capabilities are therefore favorable. The present study addressed the
E J Putz et al.
PloS one, 14(10), e0223483-e0223483 (2019-10-10)
Hapten contact hypersensitivity (CHS) elicits a well-documented inflammation response that can be used to illustrate training of immune cells through hapten-specific CHS memory. The education of hapten-specific memory T cells has been well-established, recent research in mice has expanded the
Kenjyo Miyauchi et al.
Nature chemical biology, 9(2), 105-111 (2012-12-18)
N(6)-threonylcarbamoyladenosine (t(6)A) is a universally conserved, essential modified nucleoside found in transfer RNAs (tRNAs) responsible for ANN codons in all three domains of life. t(6)A has a crucial role in maintaining decoding accuracy during protein synthesis. The presence of t(6)A
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