DLW451201
Corning® Gentest™ Buffer Phosphate 0.5M 500 mL
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About This Item
UNSPSC Code:
12352207
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concentration
0.5 M
shipped in
ambient
storage temp.
room temp
General description
Corning® Gentest™ Phosphate Buffer with pH 7, is used as assay buffer for cytochrome P450 and Phase II enzyme drug metabolism assays.
Application
Corning® Gentest™ Buffer Phosphate 0.5M 500 mL may be used as a component of homogenizing buffer for isolating microsomes from liver tissues. It has also been used as a buffer component in in vitro assay with human liver microsomes.
Legal Information
Corning is a registered trademark of Corning, Inc.
Gentest is a trademark of Corning, Inc.
Regulatory Information
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Els Van Peer et al.
Basic & clinical pharmacology & toxicology, 117(5), 350-357 (2015-04-22)
In view of paediatric drug development, regulatory authorities often request safety studies in juvenile animals, including minipigs. Unfortunately, knowledge on the ontogeny of the biotransformation processes in animal models remains scarce and impedes a correct interpretation of the toxicity findings.
In vivo and in vitro metabolism of the novel synthetic cannabinoid 5F-APINAC
Appolonova SA, et al.
Forensic Toxicology, 160-171 (2020)
Els Van Peer et al.
Pharmaceutical research, 34(4), 750-764 (2017-01-18)
In view of pediatric drug development, juvenile animal studies are gaining importance. However, data on drug metabolizing capacities of juvenile animals are scarce, especially in non-rodent species. Therefore, we aimed to characterize the in vitro biotransformation of four human CYP450
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