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D6924

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

average mol wt 9,000-20,000

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CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

form

powder

optical activity

[α]/D 90 to 105 °, c = 6% (w/v)

mol wt

average mol wt 9,000-20,000

composition

Sulfur Content, 16.0-19.0%

color

white to off-white

useful pH range

5.5 - 8.0

solubility

H2O: 100 mg/mL

storage temp.

room temp

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General description

Dextran sulfate sodium is a natural polymer of α-1,6-D-glucopyranose. It is a hydrophilic, biodegradable, and biocompatible polyanionic polymer. This highly branched polysaccharide has 1,6 and 1,4 glycosidic linkages, consisting of 2.3 sulfate groups per glucosyl unit.

Application

Dextran sulfate sodium salt from Leuconostoc spp. has been used:
  • to evaluate the participation of sulfated glycans on the interaction of recombinant human proacrosin/acrosin with zona pellucida (ZP) glycoproteins
  • to inject into the vitreous cavity of embryonic day five chick embryos to assess the eye size and to study its impact on cell proliferation in the retina
  • to test the structural specificity of binding of TNF-stimulated gene 6 (TSG-6) to immobilized hyaluronan (HA)

Biochem/physiol Actions

Dextran sulfate may exhibit anti-coagulant and antiviral properties. It may also help to lower cholesterol levels. It is extensively used as a plasma volume expander and fibrinolytic in the medical field. Dextran sulfate can also be used as a cross-linker for chitosan (CH).

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the sulfate content of Product D6924, Dextran sulfate sodium salt?

    The sulfate content is approximately 17%, which corresponds to two sulfate groups per glucose unit.

  4. Can solutions of Product D6924, Dextran sulfate sodium salt, be autoclaved?

    Neutral solutions of dextran sulfate may be sterilized by autoclaving at 110-115°C for 30 minutes.

  5. What is the average molecular weight for Product D6924, Dextran sulfate sodium salt?

    The average molecular weight can vary from lot-to-lot. Lot number 068K1121 has an average molecular weight of 15.6 kDa.

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Laura I Furlong et al.
Fertility and sterility, 83(6), 1780-1790 (2005-06-14)
To characterize proacrosin/acrosin interaction with isolated zona pellucida (ZP) components. Prospective study. Basic research laboratory. Recombinant proteins derived from human proacrosin (Rec-40, Rec-30, Rec-20, Rec-10, and Rec-6) and from human ZP glycoproteins (rec-hZPA, ZPB, and ZPC). In vitro binding assay
Willi Halfter
Investigative ophthalmology & visual science, 49(8), 3289-3298 (2008-03-26)
The vitreous body (VB) is a transparent, extracellular matrix structure that fills the vitreous cavity of the eye. Major constituents of the VB are hyaluronic acid (HA) and glycosaminoglycans (GAGs), both of which are highly charged, linear carbohydrate polymers. The
Osama A Madkhali et al.
Scientific reports, 11(1), 9914-9914 (2021-05-12)
The purpose of this study was to develop a novel nano antibacterial formulation of dextran sulfate sodium polymer. The dextran sulfate sodium (DSS) nanoparticles were formulated with gelation technique. The nanoparticles exhibited significant physicochemical and effective antibacterial properties, with zeta
Hans-Georg Wisniewski et al.
The Journal of biological chemistry, 280(15), 14476-14484 (2005-02-09)
TSG-6 protein, up-regulated in inflammatory lesions and in the ovary during ovulation, shows anti-inflammatory activity and plays an essential role in female fertility. Studies in murine models of acute inflammation and experimental arthritis demonstrated that TSG-6 has a strong anti-inflammatory
Yi-Nan Zhang et al.
ACS nano, 14(8), 9478-9490 (2020-06-02)
Nanovaccines need to be transported to lymph node follicles to induce humoral immunity and generate neutralizing antibodies. Here, we discovered that subcapsular sinus macrophages play a barrier role to prevent nanovaccines from accessing lymph node follicles. This is illustrated by

Articles

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the mild, yet adaptable LbL technique.

Protocols

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

Related Content

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

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