D6518
Diethylenetriaminepentaacetic acid
≥99% (titration)
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥99% (titration)
form
powder
mp
219-220 °C (lit.)
solubility
1 M HCl: 50 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O
InChI
1S/C14H23N3O10/c18-10(19)5-15(1-3-16(6-11(20)21)7-12(22)23)2-4-17(8-13(24)25)9-14(26)27/h1-9H2,(H,18,19)(H,20,21)(H,22,23)(H,24,25)(H,26,27)
InChI key
QPCDCPDFJACHGM-UHFFFAOYSA-N
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General description
Application
- for cofilin activity assay
- to determine the specificity of superoxide in the transverse aortic constriction (TAC) hearts
- for Europium bead-based detection assays
- to detect reduced (S- active) or irreversibly oxidized (SO3H inactive) tyrosine-protein phosphatase non-receptor type 6 (SHP-1) in thymocytes
Preparation Note
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
Target Organs
Respiratory Tract
WGK
WGK 2
Flash Point(F)
392.0 °F
Flash Point(C)
200 °C
Certificates of Analysis (COA)
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How can I get Product D6518, Diethylenetriaminepentaacetic acid, to dissolve?
As is the case with other chelating agents such as EDTA and EGTA, the solubility of DTPA is a function of pH. Therefore, this compound can be solubilized with either the addition of acid such as a hydrochloric acid solution or (more likely) base such as a sodium hydroxide solution .
What are the pKa values for Product D6518, Diethylenetriaminepentaacetic acid?
The pKa values for the carboxyl groups as reported in the reference book "Data for Biochemical Research, 3rd ed., page 402, Oxford University Press, New York (1986)." are 1.8, 2.6, 4.4, 8.8, and 10.4.
What cations can be chelated with Product D6518, Diethylenetriaminepentaacetic acid (DTPA)?
DTPA forms stable complexes with most divalent and trivalent cations. Some examples are Fe3+, Cu2+, Ni2+, Pb2+, Zn2+, Fe2+, Mn2+, Ca2+, Mg2+, and Ba2+.
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