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Merck
CN

D6003

Digoxin

analytical standard

Synonym(s):

12β-Hydroxydigitoxin

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About This Item

Empirical Formula (Hill Notation):
C41H64O14
CAS Number:
20830-75-5
Molecular Weight:
780.94
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329798818
EC Number:
244-068-1
Beilstein/REAXYS Number:
77011
MDL number:
MFCD00003674

Key Documents

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Product Name

Digoxin, analytical standard

InChI key

LTMHDMANZUZIPE-PUGKRICDSA-N

InChI

1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

SMILES string

C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4

biological source

plant (Digitalis lanata)

grade

analytical standard

assay

≥95.0% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

methanol: methylene chloride (1:1): 0.5%, clear, colorless

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

functional group

ketone

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... ATP1A1(476), ATP1A2(477), ATP1A3(478), ATP1A4(480), ATP1B1(481), ATP1B2(482), ATP1B3(483), FXYD2(486)

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Application

Digoxin may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).
A cardiac glycoside, substrate for Pgp.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5223
BCCF1947
BCCM5546
BCCD9767
BCCD4453

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Simultaneous determination of digoxin and permeability markers in rat in situ intestinal perfusion samples by RP-HPLC
Varma.S.V M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 813(1-2), 347-352 (2004)
Combined liquid chromatography/radioimmunoassay with improved specificity for serum digoxin
Gault H.M, et al.
Clinical Chemistry, 31(8), 1272-1277 (1985)
Kovi Bessoff et al.
Antimicrobial agents and chemotherapy, 57(4), 1804-1814 (2013-02-06)
Cryptosporidiosis, a diarrheal disease usually caused by Cryptosporidium parvum or Cryptosporidium hominis in humans, can result in fulminant diarrhea and death in AIDS patients and chronic infection and stunting in children. Nitazoxanide, the current standard of care, has limited efficacy
Melanie L Lawrence et al.
Scientific reports, 5, 9092-9092 (2015-03-15)
Recent advances in renal tissue engineering have shown that dissociated, early renogenic tissue from the developing embryo can self-assemble into morphologically accurate kidney-like organs arranged around a central collecting duct tree. In order for such self-assembled kidneys to be useful
Adriana Katz et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(44), 13723-13728 (2015-10-21)
The ciliary epithelium in the eye consists of pigmented epithelial cells that express the α1β1 isoform of Na,K-ATPase and nonpigmented epithelial cells that express mainly the α2β3 isoform. In principle, a Na,K-ATPase inhibitor with selectivity for α2β3 that penetrates the
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Protocols

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

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