D4285
(±)-Dropropizine
analytical standard, for drug analysis
Synonym(s):
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
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About This Item
Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
Molecular Weight:
236.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
241-683-7
MDL number:
InChI
1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
InChI key
PTVWPYVOOKLBCG-UHFFFAOYSA-N
SMILES string
OCC(O)CN1CCN(CC1)c2ccccc2
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
General description
(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.
Application
(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
G Luporini et al.
The European respiratory journal, 12(1), 97-101 (1998-08-13)
Nonproductive cough is a frequent and distressing symptom in patients with lung cancer, and it is not even relieved by palliative chemotherapy. A double-blind, randomized clinical trial regarding the treatment of nonproductive cough was performed in 140 adults with primary
Francesco De Blasio et al.
Pulmonary pharmacology & therapeutics, 25(5), 337-342 (2012-07-10)
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute
G Banderali et al.
The Journal of international medical research, 23(3), 175-183 (1995-05-01)
The antitussive efficacy and tolerability of dropropizine and of its enantiomer levodropropizine were evaluated in children with non-productive cough; 258 were evaluable for tolerability and 254 for efficacy. Patients randomly received either 1 mg/kg dropropizine or 2 mg/kg levodropropizine orally
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