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CN

D0720800

Dexchlorpheniramine maleate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

S-(+)-Chlorpheniramine maleate salt, (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
2438-32-6
Molecular Weight:
390.86
NACRES:
NA.24
PubChem Substance ID:
329798631
UNSPSC Code:
41116107
MDL number:
MFCD00079046

Key Documents

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Product Name

Dexchlorpheniramine maleate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2

InChI key

DBAKFASWICGISY-DASCVMRKSA-N

grade

pharmaceutical primary standard

API family

dexchlorpheniramine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... HRH1(3269)

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Related Categories

Application

Dexchlorpheniramine maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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José R Villada et al.
Journal of cataract and refractive surgery, 31(3), 620-621 (2005-04-07)
We report a severe anaphylactic reaction that occurred about 5 minutes after 1.0 mg of cefuroxime was injected into the anterior chamber after routine phacoemulsification and intraocular lens implantation. The patient was known to be allergic to penicillin. Immediate action
Anaphylaxis induced by Anisakis.
J Antón et al.
Allergologia et immunopathologia, 36(1), 53-55 (2008-02-12)
O Cáceres Calle et al.
Allergologia et immunopathologia, 32(5), 306-309 (2004-10-01)
Dexchlorpheniramine (DH) is a classical or first generation antihistamine belonging to the ethanolamine group. Adverse effects related to these antihistamines are frequent, but the hypersensitivity reactions described in the literature since 1940 are exceptional. We report the case of a
Nilton S Viana et al.
Farmaco (Societa chimica italiana : 1989), 60(11-12), 900-905 (2005-10-18)
Formulation excipients can frequently affect the drug analysis in pharmaceuticals yielding background interference by ultraviolet spectrophotometry. Sample separation procedures to diminish such interferences are usually recommended as sample pre-treatment, however it can be difficult to eliminate them and they can
Anaphylactic reaction to ranitidine and dexchlorpheniramine.
C Thurot-Guillou et al.
European journal of dermatology : EJD, 17(2), 170-171 (2007-03-06)
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