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D0700000

Dexamethasone

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
Empirical Formula (Hill Notation):
C22H29FO5
CAS Number:
50-02-2
Molecular Weight:
392.46
Beilstein:
2066651
EC Number:
200-003-9
MDL number:
MFCD00064136
UNSPSC Code:
41116107
PubChem Substance ID:
329798628
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

API family

dexamethasone

packaging

pkg of 50 mg

manufacturer/tradename

EDQM

storage condition

protect from light

mp

262-264 °C (lit.)

solubility

water: <0.1 g/L

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone EP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

1177000

Dexamethasone phosphate, United States Pharmacopeia (USP) Reference Standard

D0710000

Dexamethasone acetate, European Pharmacopoeia (EP) Reference Standard

D0720000

Dexamethasone sodium phosphate, European Pharmacopoeia (EP) Reference Standard

D0718000

Dexamethasone pivalate, European Pharmacopoeia (EP) Reference Standard

Y0000511

Dexamethasone isonicotinate for impurity C identification, European Pharmacopoeia (EP) Reference Standard

Y0000538

Dexamethasone isonicotinate, European Pharmacopoeia (EP) Reference Standard

Y0001177

Dexamethasone for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001169

Dexamethasone acetate impurity E, European Pharmacopoeia (EP) Reference Standard

Y0001477

Dexamethasone sodium phosphate for peak identification, European Pharmacopoeia (EP) Reference Standard

Y0001593

Dexamethasone for peak identification, European Pharmacopoeia (EP) Reference Standard

1176506

Dexamethasone acetate, United States Pharmacopeia (USP) Reference Standard

1176007

Dexamethasone, United States Pharmacopeia (USP) Reference Standard

PHR1527

Dexamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

BP578

Dexamethasone, British Pharmacopoeia (BP) Assay Standard

1177032

Dexamethasone sodium phosphate, United States Pharmacopeia (USP) Reference Standard

PHR1768

Dexamethasone Sodium Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

BP108

Dexamethasone sodium phosphate, British Pharmacopoeia (BP) Reference Standard

PHR1628

Dexamethasone Phosphate, Pharmaceutical Secondary Standard; Certified Reference Material

BP811

Dexamethasone impurity standard, British Pharmacopoeia (BP) Reference Standard

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD

Hazard Classifications

Repr. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dexamethasone
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 4961-4963 (2021)
Spectrophotometric resolution of ternary mixtures of Dexamethasone, Polymyxin B and Trimethoprim in synthetic and pharmaceutical formulations
Gallego JML and Arroyo JP
Analytica Chimica Acta, 437(2), 247-257 (2001)
Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: Naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension
Raith K, et al.
Electrophoresis, 19(16-17), 2907-2911 (1998)
Determination of prednisolone, dexamethasone and hydrocortisone in pharmaceutical formulations and biological fluid samples by voltammetric techniques using b-cyclodextrin modified carbon paste electrode
Balaji K, et al.
African Journal of Pharmacy and Pharmacology, 2(8), 157-166 (2008)
Fullerene-C60-modified edge plane pyrolytic graphite electrode for the determination of dexamethasone in pharmaceutical formulations and human biological fluids
Goyal RN, et al.
Biosensors And Bioelectronics, 24(6), 1649-1654 (2009)
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