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C8731

Sigma-Aldrich

Calcium pantothenate

meets USP testing specifications, monograph mol wt. 476.53 (C18H32CaN2O10)

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Synonym(s):
D-Pantothenic acid hemicalcium salt, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5
Linear Formula:
HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
CAS Number:
137-08-6
Molecular Weight:
238.27
Beilstein:
3769272
EC Number:
205-278-9
MDL number:
MFCD00002766
UNSPSC Code:
12352205
eCl@ss:
34058012
PubChem Substance ID:
24893098
NACRES:
NA.21

biological source

synthetic (organic)

Quality Level

200

Agency

USP/NF
meets USP testing specifications

form

crystalline
powder

mol wt

monograph mol wt. 476.53 (C18H32CaN2O10)

technique(s)

cell culture | mammalian: suitable
cell culture | plant: suitable

color

white

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

InChI key

FAPWYRCQGJNNSJ-UBKPKTQASA-L

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General description

Vitamin B5 or pantothenic acid is a viscous oil that is soluble in ethanol and water. It is produced by plants and microorganisms. d-(+)pantothenic acid is the naturally occurring form of pantothenic acid and is biologically active.

Application

Calcium pantothenate has been used:
  • as a component of vitamin solution for synthetic media
  • as a component of vitamin mix for the ICS medium mix
  • as a component of a chemically defined diet for metal depletion studies in Drosophila
  • as a supplement to study coenzyme A metabolism in mouse models of non-alcoholic steatohepatitis
Precursor in the biosynthesis of coenzyme A.

Biochem/physiol Actions

The calcium salts of panthenol are commonly used for pharmaceutical preparations. Pantothenate is a component of coenzyme A and is useful in its synthesis. Pantothenic acid is also involved in the synthesis of heme, cholesterol and fatty acids. Since vitamin B5 is found in all foods, its deficiency is not commonly observed.

Physical properties

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Vitamin B5 and N-acetylcysteine in nonalcoholic steatohepatitis: a preclinical study in a dietary mouse model
Machado MV, et al.
Digestive Diseases and Sciences, 61(1) (2016)
Salway JG
Medical Biochemistry (2011)
Nohr D and Biesalski HK
Reference Module in Life Sciences (2016)
Long-term in vitro Culture of Cryptosporidium parvum
Yarlett N and Morada M
Bio-protocol, 8(15) (2018)
Properties of vitamins
Combs Jr
The Vitamins (2016)
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