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C2360000

Clomipramine hydrochloride

for microbiological assay, European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
Empirical Formula (Hill Notation):
C19H23ClN2 · HCl
CAS Number:
17321-77-6
Molecular Weight:
351.31
MDL number:
MFCD00069234
UNSPSC Code:
41116107
PubChem Substance ID:
329774996
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

clomipramine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI key

WIMWMKZEIBHDTH-UHFFFAOYSA-N

Gene Information

human ... SLC6A4(6532)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clomipramine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0000132

Clomipramine impurity C, European Pharmacopoeia (EP) Reference Standard

Y0000134

Clomipramine impurity F, European Pharmacopoeia (EP) Reference Standard

Y0000133

Clomipramine impurity D, European Pharmacopoeia (EP) Reference Standard

1140247

Clomipramine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1140292

Clomipramine Related Compound F, United States Pharmacopeia (USP) Reference Standard

1140269

Clomipramine Related Compound C, United States Pharmacopeia (USP) Reference Standard

1140270

Clomipramine Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP980

Clomipramine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP982

Clomipramine impurity D, British Pharmacopoeia (BP) Reference Standard

BP983

Clomipramine impurity F, British Pharmacopoeia (BP) Reference Standard

Signal Word

Danger

Hazard Statements

H302,H336,H370,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

Target Organs

Central nervous system, Central nervous system,Cardiovascular

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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D F Horwitz
Journal of the American Animal Hospital Association, 36(2), 107-109 (2000-03-24)
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A fast and efficient method for the determination of tricyclic antidepressants using electro-enhanced solid phase microextraction (SPME) coupled to gas chromatography-mass spectrometry (GC-MS) has been developed. One advantage of this approach is that the mass transfer of target analytes from
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Journal of pharmaceutical sciences, 104(4), 1409-1420 (2015-02-26)
We have developed a predictive method, based on quantum chemical calculations, that qualitatively predicts N-oxidation by hydrogen peroxides in drug structures. The method uses linear correlations of two complementary approaches to estimate the activation barrier without calculating it explicitly. This
Knut Fredrik Seip et al.
Journal of chromatography. A, 1347, 1-7 (2014-05-06)
Electromembrane extraction (EME) was performed on samples containing substantial amounts of NaCl to investigate how the presence of salts affected the recovery, repeatability, and membrane current in the extraction system. A group of 17 non-polar basic drugs with various physical

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