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Merck
CN

C2300000

Clofibrate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester, Ethyl 2-(4-chlorophenoxy)-2-methylpropionate, Ethyl 2-(4-chlorophenoxy)isobutyrate

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About This Item

Empirical Formula (Hill Notation):
C12H15ClO3
CAS Number:
637-07-0
Molecular Weight:
242.70
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329774991
MDL number:
MFCD00000615
Beilstein/REAXYS Number:
1913459

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InChI

1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

SMILES string

CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1

InChI key

KNHUKKLJHYUCFP-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

clofibrate

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... PPARA(5465)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Clofibrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

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G Calais et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 22(2), 99-103 (1991-10-01)
It is generally accepted that hypoxia is a common occurrence in many experimental and human tumours and that it is a major cause of local failure after radiotherapy. Many attempts have been made over the last years to eliminate this
H M Mehendale
Toxicological sciences : an official journal of the Society of Toxicology, 57(2), 187-190 (2000-09-28)
The article highlighted in this issue is "Peroxisome Proliferator-Activated Receptor Alpha-Null Mice Lack Resistance to Acetaminophen Hepatotoxicity Following Clofibrate Exposure" by Chuan Chen, Gayle E. Hennig, Herbert E. Whiteley, J Christopher Corton, and José E. Manautou (pp. 338-344).
Clofibrate myopathy: a case report and a review of the literature.
P Rush et al.
Seminars in arthritis and rheumatism, 15(3), 226-229 (1986-02-01)
F Penna et al.
Current medicinal chemistry, 17(4), 309-320 (2009-12-18)
The biological activity of peroxisome proliferators (PPs) is mediated by a class of receptors, known as PPARs (PP-Activated Receptor), belonging to the nuclear receptor superfamily. Upon ligand binding, PPARs dimerize with retinoid receptors, translocate to the nucleus, recognize specific PP-responsive
S Oikawa et al.
Nihon rinsho. Japanese journal of clinical medicine, 52(12), 3285-3291 (1994-12-01)
Clofibrate has cholesterol- and triglyceride-lowering effect. They affect on the various points in the metabolic pathway of lipoproteins. They improve VLDL-synthesis in liver and increase the activity of LPL and hepatic TG lipase. As the results, HDL-cholesterol increases and LDL
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