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Merck
CN

C1800000

Chlorphenamine maleate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(±)-Chlorpheniramine maleate salt

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About This Item

Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
113-92-8
Molecular Weight:
390.86
NACRES:
NA.24
PubChem Substance ID:
329774908
UNSPSC Code:
41116107
MDL number:
MFCD00069225

Key Documents

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Product Name

Chlorphenamine maleate, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES string

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

InChI key

DBAKFASWICGISY-BTJKTKAUSA-N

grade

pharmaceutical primary standard

API family

chlorpheniramine

manufacturer/tradename

EDQM

mp

130-135 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... HRH1(3269)

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Related Categories

Application

Chlorphenamine maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

H1 Histamine receptor antagonist.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Matthieu Lafaurie et al.
Annales de medecine interne, 154(3), 179-180 (2003-08-12)
Drug-induced aseptic meningitis has been reported mainly with the use of nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins and OKT3 antibodies. We describe today a very unusual reaction on intravenous dexchlorpheniramine with this case of aseptic meningitis.
José R Villada et al.
Journal of cataract and refractive surgery, 31(3), 620-621 (2005-04-07)
We report a severe anaphylactic reaction that occurred about 5 minutes after 1.0 mg of cefuroxime was injected into the anterior chamber after routine phacoemulsification and intraocular lens implantation. The patient was known to be allergic to penicillin. Immediate action
Anaphylactic reaction to ranitidine and dexchlorpheniramine.
C Thurot-Guillou et al.
European journal of dermatology : EJD, 17(2), 170-171 (2007-03-06)
Urticaria due to aloe vera: a new sensitizer?
Alberto Alvarez-Perea et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 105(5), 404-405 (2010-11-09)
Eef L Theunissen et al.
British journal of clinical pharmacology, 61(1), 79-86 (2006-01-05)
Previous studies have demonstrated that the antihistamines mequitazine, cetirizine and dexchlorpheniramine produce mild sedation after single doses. It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines
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