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C1540000

Chlorhexidine dihydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide), Lisium

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About This Item

Empirical Formula (Hill Notation):
C22H30Cl2N10 · 2HCl
CAS Number:
3697-42-5
Molecular Weight:
578.37
MDL number:
MFCD00068998
UNSPSC Code:
41116107
PubChem Substance ID:
329774895
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

chlorhexidine

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10.2ClH/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H

InChI key

WJLVQTJZDCGNJN-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorhexidine dihydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Claudius Gmür et al.
Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia, 123(5), 394-409 (2013-05-31)
Five to ten percent of all hospitalized patients are treated in intensive care units. The risk of nosocomial infections is inherent in the latter, especially in cases of intubation. In this context, impaired oral hygiene may play a pivotal role.
Daily chlorhexidine bathing and hospital-acquired infection.
Anthony L Esposito
The New England journal of medicine, 368(24), 2330-2330 (2013-06-14)
Daily chlorhexidine bathing and hospital-acquired infection.
Michael W Climo et al.
The New England journal of medicine, 368(24), 2332-2332 (2013-06-14)
Daily chlorhexidine bathing and hospital-acquired infection.
Jean-Jacques Parienti et al.
The New England journal of medicine, 368(24), 2331-2331 (2013-06-14)
Matthew Toomey
AANA journal, 81(3), 209-214 (2013-08-09)
Chlorhexidine is a synthetic antiseptic and disinfectant that has been widely used in the healthcare setting and in everyday household products. In addition to oral rinses and skin preparations, manufacturers have incorporated chlorhexidine coatings into medical devices such as urinary
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