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C1510000

Chlorhexidine

Name: Chlorhexidine
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]

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About This Item

Linear Formula:

[-(CH₂)₃NHC(=NH)NHC(=NH)NHC₆H₄Cl]₂

CAS Number:

55-56-1

Molecular Weight:

505.45

Beilstein:

2826432

MDL number:

MFCD00009673

UNSPSC Code:

41116107

PubChem Substance ID:

329774893

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

chlorhexidine

manufacturer/tradename

EDQM

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

InChI key

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

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Chromatography Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorhexidine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Danger

Hazard Statements

H318,H410

Precautionary Statements

P273 - P280 - P305 + P351 + P338 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

WGK

WGK 3

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Reduced susceptibility to chlorhexidine in staphylococci: is it increasing and does it matter?

Carolyne Horner et al.

The Journal of antimicrobial chemotherapy, 67(11), 2547-2559 (2012-07-27)

Antiseptic agents are increasingly used for hand hygiene and skin decolonization as key tools for the prevention of healthcare-associated infections. Chlorhexidine, a divalent, cationic biguanide, has a broad spectrum of activity and is one of the most frequently used topical

Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis.

Richard Price et al.

BMJ (Clinical research ed.), 348, g2197-g2197 (2014-04-02)

To determine the effect on mortality of selective digestive decontamination, selective oropharyngeal decontamination, and topical oropharyngeal chlorhexidine in adult patients in general intensive care units and to compare these interventions with each other in a network meta-analysis. Systematic review, conventional

The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis.

Matthias Maiwald et al.

PloS one, 7(9), e44277-e44277 (2012-09-18)

Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought

Effects of intra-alveolar placement of 0.2% chlorhexidine bioadhesive gel on dry socket incidence and postsurgical pain: a double-blind split-mouth randomized controlled clinical trial.

Afshin Haraji et al.

Journal of orofacial pain, 27(3), 256-262 (2013-07-25)

To assess the effects of intra-alveolar application of chlorhexidine gel on the incidence of alveolar osteitis (dry socket) and the severity of postsurgical pain. A total of 160 impacted mandibular third molars were extracted in 80 patients enrolled in this

Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial.

Lennie P G Derde et al.

The Lancet. Infectious diseases, 14(1), 31-39 (2013-10-29)

Intensive care units (ICUs) are high-risk areas for transmission of antimicrobial-resistant bacteria, but no controlled study has tested the effect of rapid screening and isolation of carriers on transmission in settings with best-standard precautions. We assessed interventions to reduce colonisation

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