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Merck
CN

C0415

Ciclopirox olamine

analytical standard

Synonym(s):

6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolammonium salt

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About This Item

Empirical Formula (Hill Notation):
C12H17NO2 · C2H7NO
CAS Number:
41621-49-2
Molecular Weight:
268.35
UNSPSC Code:
41116107
PubChem Substance ID:
329774787
EC Number:
255-464-9
MDL number:
MFCD00078997

Key Documents

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InChI key

MBRHNTMUYWQHMR-UHFFFAOYSA-N

InChI

1S/C12H17NO2.C2H7NO/c1-9-7-11(13(15)12(14)8-9)10-5-3-2-4-6-10;3-1-2-4/h7-8,10,15H,2-6H2,1H3;4H,1-3H2

SMILES string

NCCO.CC1=CC(=O)N(O)C(=C1)C2CCCCC2

grade

analytical standard

assay

≥97%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN4527V
SLBK8794V
SLBF9186V
SLBF8062V
041M1460V

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Aditya K Gupta et al.
The Journal of dermatological treatment, 25(3), 256-259 (2012-05-30)
Computerized nail planimetry is an objective means of accurately assessing affected nail areas, versus the standard visual estimation method. However, no published comparison of visual assessment with planimetry is currently available on onychomycosis to support this recommendation. This article evaluates
P Chouhan et al.
International journal of pharmaceutics, 436(1-2), 179-182 (2012-06-19)
Drug delivery by topical route for the treatment of onychomycosis, a nail fungal infection, is challenging due to the unique barrier properties of the nail plate which imparts high resistance to the passage of antifungal drugs. Permeation enhancers are used
Sae Hee Ko et al.
PloS one, 6(11), e27844-e27844 (2011-11-30)
Diabetic wounds remain a major medical challenge with often disappointing outcomes despite the best available care. An impaired response to tissue hypoxia and insufficient angiogenesis are major factors responsible for poor healing in diabetic wounds. Here we show that the
Siyuan Song et al.
Cancer research, 71(24), 7628-7639 (2011-10-20)
Excessive signaling from the Wnt pathway is associated with numerous human cancers. Using a high throughput screen designed to detect inhibitors of Wnt/β-catenin signaling, we identified a series of acyl hydrazones that act downstream of the β-catenin destruction complex to
D Monti et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 27(2), e153-e158 (2012-03-28)
In a previous study a new hydrosoluble nail lacquer (P-3051) containing 8% ciclopirox (CPX) showed higher nail penetration compared to a water-insoluble 5% amorolfine (MRF) lacquer. To our knowledge, in vivo human data on a similar topic are not available.
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