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BP854

Chloramphenicol

British Pharmacopoeia (BP) Reference Standard

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Synonym(s):
D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin
Linear Formula:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
CAS Number:
56-75-7
Molecular Weight:
323.13
Beilstein:
2225532
EC Number:
200-287-4
MDL number:
MFCD00078159
UNSPSC Code:
12352200
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

chloramphenicol

form

powder

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

149-153 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

InChI key

WIIZWVCIJKGZOK-RKDXNWHRSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chloramphenicol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Chloramphenicol Eye Drops
  • Chloramphenicol Sodium Succinate Injection
  • Chloramphenicol Capsules
  • Chloramphenicol Ear Drops
  • Chloramphenicol Eye Ointment

    • Biochem/physiol Actions

    Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

    Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

    Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

    Packaging

    Unit quantity: 500 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    related product

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    C1425000

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    C1350000

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    PHR1412

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    1107004

    Chloramphenicol, United States Pharmacopeia (USP) Reference Standard

    1107300

    Chloramphenicol palmitate, United States Pharmacopeia (USP) Reference Standard

    1107401

    Chloramphenicol palmitate nonpolymorph A, United States Pharmacopeia (USP) Reference Standard

    1107503

    Chloramphenicol palmitate polymorph A, United States Pharmacopeia (USP) Reference Standard

    BP1061

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    BP417

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    Pictograms

    Health hazardCorrosion
    GHS08,GHS05

    Signal Word

    Danger

    Hazard Statements

    H318,H351,H361fd

    Hazard Classifications

    Carc. 2 - Eye Dam. 1 - Repr. 2

    WGK

    WGK 3

    Regulatory Information

    监管及禁止进口产品

    Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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