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Merck
CN

BP787

Colecalciferol

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

Cholecalciferol, (+)-Vitamin D3, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol

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About This Item

Empirical Formula (Hill Notation):
C27H44O
CAS Number:
67-97-0
Molecular Weight:
384.64
EC Number:
200-673-2
UNSPSC Code:
41116107
NACRES:
NA.24
Beilstein/REAXYS Number:
2339331
MDL number:
MFCD00078131

Key Documents

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Product Name

Colecalciferol, British Pharmacopoeia (BP) Reference Standard

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

SMILES string

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

grade

pharmaceutical primary standard

API family

cholecalciferol

form

crystalline

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

color

white

mp

83-86 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

−20°C

Gene Information

human ... VDR(7421)

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Related Categories

Application

Colecalciferol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Alendronic Acid and Colecalciferol Tablets
  • Colecalciferol Injection
  • Paediatric Vitamins A, C and D Oral Drops
  • Colecalciferol Tablets
  • Calcium and Colecalciferol Chewable Tablets
  • Calcium and Ergocalciferol Tablets
  • Calcium and Ergocalciferol Chewable Tablets
  • Ergocalciferol Tablets
  • Calcium and Colecalciferol Tablets

    • Biochem/physiol Actions

    Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
    Vitamin D acts through a receptor that modulates the proliferation and differentiation of both normal and cancer cells.

    General description

    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

    Colecalciferol is a fat soluble vitamin, which participates in the calcium and phosphate metabolism. It is sourced either through the diet or by exposing skin to ultraviolet rays. Oral administration of vitamin D3 is readily absorbed and is stored in adipose tissue.

    Other Notes

    Sales restrictions may apply.
    Learn how British Pharmacopoeia (BP) sets the standard by offering quality British Pharmacopoeia Chemical Reference Substances (BPCRS).

    Packaging

    Unit quantity: 500 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    pictograms

    Skull and crossbonesHealth hazard
    GHS06,GHS08

    signalword

    Danger

    Hazard Classifications

    Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

    Storage Class

    6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

    wgk

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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