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BP460

Nicotinamide

British Pharmacopoeia (BP) Reference Standard

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Synonym(s):
NAM, NIC, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP
Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
98-92-0
Molecular Weight:
122.12
Beilstein:
383619
MDL number:
MFCD00006395
UNSPSC Code:
12352200
NACRES:
NA.24

grade

pharmaceutical primary standard

Agency

BP

API family

nicotinamide

form

solid

manufacturer/tradename

BP

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

128-131 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Nicotinamide, a member of the family of water-soluble B vitamins, is generally produced from nicotinic acid (vitamin B3). It is often present in food products. It has been reported to have been effective in the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It is also shown to possess anti-inflammatory activity.

Application

Nicotinamide BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Vitamins B and C Injection
  • Nicorandil Tablets

    • Biochem/physiol Actions

    Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    related product

    Product No.
    Description
    Pricing

    N0600000

    Nicotinamide, European Pharmacopoeia (EP) Reference Standard

    PHR1033

    Niacinamide, Pharmaceutical Secondary Standard; Certified Reference Material

    1462006

    Niacinamide, United States Pharmacopeia (USP) Reference Standard

    E2400000

    Ethylnicotinamide, European Pharmacopoeia (EP) Reference Standard

    BP1104

    N-(2-Hydroxyethyl)isonicotinamide nitric ester, British Pharmacopoeia (BP) Reference Standard

    PHR2089

    Nicotinamide Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2090

    Nicotinamide Impurity E, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2088

    Nicotinamide Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

    PHR2087

    Nicotinamide Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

    Pictograms

    Exclamation mark
    GHS07

    Signal Word

    Warning

    Hazard Statements

    H319

    Hazard Classifications

    Eye Irrit. 2

    WGK

    WGK 1

    Flash Point(F)

    302.0 °F

    Flash Point(C)

    150 °C

    Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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    Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
    Chatzimichalakis PF, et al.
    Journal of Separation Science, 27(14), 1181-1188 (2004)
    Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
    Soares FLF and Carneiro RL
    Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
    Nicotinamide
    European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
    European pharmacopoeia, 14(4), 3145-3146 (2017)
    Simultaneous determination and classification of riboflavin, thiamine, nicotinamide and pyridoxine in pharmaceutical formulations, by UV-visible spectrophotometry and multivariate analysis
    Lopez-de-Alba LP, et al.
    Journal of the Brazilian Chemical Society, 17(4), 715-722 (2006)
    Youdan Shi et al.
    International immunopharmacology, 14(4), 530-537 (2012-10-13)
    Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of NAM and suggests it may be used as a novel strategy in the prevention

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