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BP030

Beclometasone (beclomethasone) dipropionate

British Pharmacopoeia (BP) Assay Standard

Synonym(s):

Beclomethasone dipropionate, 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

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About This Item

Empirical Formula (Hill Notation):
C28H37ClO7
CAS Number:
5534-09-8
Molecular Weight:
521.04
EC Number:
226-886-0
MDL number:
MFCD00135613
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

beclometasone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChI key

KUVIULQEHSCUHY-XYWKZLDCSA-N

Gene Information

human ... NR3C1(2908)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Beclometasone (beclomethasone) dipropionate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Beclometasone Pressurised Inhalation
  • Betamethasone and Clioquinol Cream
  • Betamethasone and Clioquinol Ointment
  • Betamethasone Valerate Cream
  • Betamethasone Valerate Ointment
  • Betamethasone Valerate Lotion
  • Beclometasone Inhalation Powder
  • Beclometasone Inhalation Powder, pre-metered
  • Clobetasol Cutaneous Foam
  • Betamethasone Valerate and Coal Tar Paste
  • Clobetasol Cream
  • Beclometasone Cream
  • Clobetasol Shampoo
  • Beclometasone Ointment
  • Clobetasol Scalp Application
  • Clobetasol Ointment
  • Beclometasone Aqueous Nasal Spray

    • Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

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    Pictograms

    Health hazard
    GHS08

    Signal Word

    Warning

    Hazard Statements

    H361fd,H373

    Hazard Classifications

    Repr. 2 - STOT RE 2

    Target Organs

    Adrenal gland,Immune system,Bone

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Regulatory Information

    监管及禁止进口产品

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    Certificates of Analysis (COA)

    Lot/Batch Number

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    Dexter J D'Sa et al.
    Pharmaceutical research, 31(10), 2716-2723 (2014-04-25)
    The techniques available to study formulation stability in pressurized metered dose inhalers (pMDIs) are limited, due to the challenging conditions of working with high pressure propellants. Isothermal microcalorimetry is a valuable tool used to screen and aid in formulation development
    Carlos E Rodríguez-Martínez et al.
    Advances in therapy, 32(3), 254-269 (2015-03-11)
    Allergic rhinitis (AR) is one of the most common chronic respiratory diseases observed in the pediatric population, producing a significant morbidity, and an economic burden due to direct medical costs and indirect costs. Despite the high prevalence of AR in
    Bryn Flinders et al.
    Analytical and bioanalytical chemistry, 407(8), 2085-2094 (2014-11-05)
    Hydrazine-based derivatization reagents have been used to detect the presence of the carbonyl containing glucocorticoid fluticasone proprionate in rat lung tissue by MALDI-MSI. Such reagents also act as a matrix for analysis by MALDI-MS and have been termed "reactive matrices".

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