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B6506

Sigma-Aldrich

Benzamidine hydrochloride hydrate

≥99%

Synonym(s):

Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride

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5 MG
CN¥1,978.95
25 MG
CN¥6,372.41

CN¥1,978.95

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5 MG
CN¥1,978.95
25 MG
CN¥6,372.41

About This Item

Linear Formula:
C6H5C(=NH)NH2 · HCl · xH2O
CAS Number:
206752-36-5
Molecular Weight:
156.61 (anhydrous basis)
Beilstein:
3594959
EC Number:
216-795-4
MDL number:
MFCD00066285
UNSPSC Code:
12352107
PubChem Substance ID:
24278275
NACRES:
NA.77

CN¥1,978.95

Please contact Customer Service for Availability
Request a Bulk Order

biological source

synthetic (organic)

Quality Level

200

Assay

≥99%

form

powder

mp

86-88 °C (lit.)

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

Cl[H].[H]O[H].NC(=N)c1ccccc1

InChI

1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2

InChI key

BQVJCMMLDJPBFZ-UHFFFAOYSA-N

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Millipore

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Milliflex® Rapid System 2.0 power supply

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MXRPWRSPZA

Milliflex® Rapid System 2.0 power supply

Millipore

MXRPWRSPUK

Milliflex® Rapid System 2.0 power supply

Millipore

MXRPWRSPBR

Milliflex® Rapid System 2.0 power supply

packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

packaging

pkg of 1 ea

manufacturer/tradename

Milliflex®

manufacturer/tradename

Milliflex®

manufacturer/tradename

Milliflex®

manufacturer/tradename

Milliflex®

technique(s)

Rapid Sterility Testing: suitable

technique(s)

Rapid Sterility Testing: suitable

technique(s)

Rapid Sterility Testing: suitable

technique(s)

Rapid Sterility Testing: suitable

application(s)

bioburden testing
pharmaceutical
sterility testing

application(s)

bioburden testing
pharmaceutical
sterility testing

application(s)

bioburden testing
pharmaceutical
sterility testing

application(s)

bioburden testing
pharmaceutical
sterility testing

Application

Benzamidine hydrochloride hydrate has been used:
  • in western blot analysis[1][2]
  • in immunoprecipitation[3]
  • in the purification of yeast dynein[4]
  • as a protease inhibitor in the preparation of brush-border membrane vesicles[5]
  • for the processing of human synovial fluid, blood and eye sleep[6]
  • to prevent non-specific degradation of cartilages[7][8]

Biochem/physiol Actions

Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.

In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.

Preparation Note

Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000372451
    0000352676
    0000372451
    WXBF4400V
    WXBF3116

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    Aneuploidy causes premature differentiation of neural and intestinal stem cells
    Gogendeau D, et al.
    Nature Communications, 6(51), 8894-8894 (2015)
    Sialidase unmasks mucin domain epitopes of lubricin
    Solka KA, et al.
    The Journal of Histochemistry and Cytochemistry, 64(11), 647-668 (2016)
    Contrast-enhanced CT imaging as a non-destructive tool for ex vivo examination of the biochemical content and structure of the human meniscus
    Oh DJ, et al.
    Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 35(5), 1018-1028 null
    Contrast-enhanced CT using a cationic contrast agent enables non-destructive assessment of the biochemical and biomechanical properties of mouse tibial plateau cartilage
    Lakin BA, et al.
    Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(7), 1130-1138 (2016)
    Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein
    Single Molecule Analysis, 53-89 (2018)
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