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B5899

Supelco

Buflomedil hydrochloride

analytical standard

Synonym(s):

4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone

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About This Item

Empirical Formula (Hill Notation):
C17H25NO4 · HCl
CAS Number:
35543-24-9
Molecular Weight:
343.85
EC Number:
252-611-9
MDL number:
MFCD00078965
UNSPSC Code:
41116107
PubChem Substance ID:
329773268
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Cl.COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1

InChI

1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

InChI key

ZDPACSAHMZADFZ-UHFFFAOYSA-N

Gene Information

human ... EBP(10682)

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General description

Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.

Application

Buflomedil hydrochloride may be used as an analytical standard for the determination of buflomedil in biological matrices using high-performance liquid chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and serum samples using electroanalytical and chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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D Tsantilas et al.
International angiology : a journal of the International Union of Angiology, 30(2), 164-171 (2011-03-24)
The aim of this study was to assess the effects of buflomedil on the peripheral microcirculation in patients with type 2 diabetes mellitus (T2DM) without overt micro- or macroangiopathy. Twenty-three patients with T2DM were randomly assigned to receive buflomedil 600
Tine L M De Backer et al.
Drug safety, 32(4), 283-291 (2009-04-25)
Benefit-risk assessment should be ongoing during the life cycle of a pharmaceutical agent. New products are subjected to rigorous registration laws and rules, which attempt to assure the availability and validity of evidence. For older products, bias in benefit-risk assessment
Jin-Rong Tang et al.
Indian journal of pharmacology, 44(4), 480-484 (2012-10-23)
To study the effect of Buflomedil on the morphological repair on crush injury of sciatic nerve and also the expression of vascular endothelial growth factor (VEGF). Rat sciatic nerves were crushed by pincers. All of the 400 Sprague Dawley rats
L-A Dumont et al.
Chirurgie de la main, 29(2), 100-108 (2010-03-20)
Thrombosis is still the first cause of microsurgery failure. Lots of publications have been made but no consensus exists. We first analysed the results of our study in 53 French expert surgeons, then we compared them with the last published
Cutaneous granulomatous reaction from mesotherapy.
Gonca Gokdemir et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 35(2), 291-293 (2009-02-14)
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