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B4027

Supelco

Bucetin

analytical standard

Synonym(s):

3-Hydroxy-p-butyrophenetidide, N-(4-Ethoxyphenyl)-3-hydroxybutanamide

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About This Item

Empirical Formula (Hill Notation):
C12H17NO3
CAS Number:
1083-57-4
Molecular Weight:
223.27
EC Number:
214-109-8
MDL number:
MFCD00021906
UNSPSC Code:
41116107
PubChem Substance ID:
329773226
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CCOc1ccc(NC(=O)CC(C)O)cc1

InChI

1S/C12H17NO3/c1-3-16-11-6-4-10(5-7-11)13-12(15)8-9(2)14/h4-7,9,14H,3,8H2,1-2H3,(H,13,15)

InChI key

LIAWQASKBFCRNR-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H312 + H332,H350

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 1B

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
060H0913

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Mechanism of metabolic activation of the analgetic bucetin to bacterial mutagens by hamster liver microsomes.
T Nohmi et al.
Chemical & pharmaceutical bulletin, 33(7), 2877-2885 (1985-07-01)
[Biopharmaceutical studies of drugs. III. Serum concentration level of o-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine after simultaneous administration to rabbit (author's transl)].
K Kigasawa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 101(6), 556-566 (1981-06-01)
[Biopharmaceutical studies of drugs (6). Effect of 2-bromo-isovalerylurea on serum concentrations of O-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine in rabbits].
K Kigasawa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 103(5), 559-565 (1983-05-01)
[Biopharmaceutical studies of drugs (7). Inhibitory effect of urea derivatives on de-ethylation of O-ethoxybenzamide and N-(beta-hydroxybutyryl)-p-phenetidine].
K Kigasawa et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 103(5), 566-572 (1983-05-01)
K Togei et al.
Journal of the National Cancer Institute, 79(5), 1151-1158 (1987-11-01)
The carcinogenicity of bucetin [(3-hydroxy-p-butyrophenetidide) CAS: 1083-57-4], an antipyretic analgesic drug, was examined in 300 (C57BL/6 X C3H)F1 mice. Groups of 50 mice of each sex were treated with 1.5 or 0.75% bucetin in their basal diet for 76 weeks
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