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B142

Supelco

Benzoylnorecgonine

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C15H17NO4
CAS Number:
41889-45-6
Molecular Weight:
275.30
MDL number:
MFCD00153770
UNSPSC Code:
41116107
PubChem Substance ID:
329773185
NACRES:
NA.24

grade

analytical standard

Quality Level

200

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

−20°C

SMILES string

OC(=O)[C@@H]1[C@H]2CC[C@@H](C[C@@H]1OC(=O)c3ccccc3)N2

InChI

1S/C15H17NO4/c17-14(18)13-11-7-6-10(16-11)8-12(13)20-15(19)9-4-2-1-3-5-9/h1-5,10-13,16H,6-8H2,(H,17,18)/t10-,11+,12-,13+/m0/s1

InChI key

CMYJDRSCSOXYHG-QNWHQSFQSA-N

General description

Benzoylnorecgonine is a major urinary metabolite of cocaine, which can be determined by a variety of analytical techniques and is often used in toxicology screening to confirm cocaine abuse.

Application

Benzoylnorecgonine may be used as an analytical reference standard for the quantification of the analyte in cocaine based products using high-performance liquid chromatography.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

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R A Dean et al.
Toxicology and applied pharmacology, 117(1), 1-8 (1992-11-01)
The coabuse of cocaine and ethanol occurs with high frequency and increases the risk of cocaine-related morbidity and mortality. The mechanisms mediating the toxic interactions of cocaine and ethanol are not clearly defined. This study examined the effects of acute
J A Sandberg et al.
The Journal of pharmacology and experimental therapeutics, 258(2), 477-482 (1991-08-01)
The pharmacokinetics of cocaine (COC) were studied during late gestation in guinea pigs. Clearance (Cl) was not dose-dependent and the average +/- S.D. was 59 +/- 16 ml/min/kg over the i.v. dose range of 2 to 12 mg/kg. Volume of
F Ma et al.
Journal of chromatography. B, Biomedical sciences and applications, 693(2), 307-312 (1997-06-06)
A single-solvent extraction step high-performance liquid chromatographic method is described for quantitating cocaine and its three metabolites in rat serum microsamples (50 microl). The separation used a 2.1-mm I.D. reversed-phase Brownlee C18 column with an isocratic mobile phase consisting of
J A Sandberg et al.
The Journal of pharmacology and experimental therapeutics, 260(2), 587-591 (1992-02-01)
To determine the disposition of cocaine (COC) and metabolites after chronic COC exposure in the late gestation guinea pig, six time-bred Dunkin-Hartley guinea pigs were given 10 daily 6 mg/kg COC s.c. injections from day 50 of gestation. Maternal blood
R J Konkol et al.
Journal of child neurology, 9(3), 242-248 (1994-07-01)
Recent reports indicate that cocaine metabolites have biologic activity and could be toxic. To explore this possibility, two studies were initiated. The first study aimed to define the distribution of cocaine species by quantifying levels of cocaine and its metabolites
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