B0490000
Benzarone
European Pharmacopoeia (EP) Reference Standard
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Synonym(s):
(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134
Empirical Formula (Hill Notation):
C17H14O3
Recommended Products
grade
pharmaceutical primary standard
API family
benzarone
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3
InChI key
RFRXIWQYSOIBDI-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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H Köstering et al.
Arzneimittel-Forschung, 35(8), 1303-1306 (1985-01-01)
The analyses on hemostaseological variables are recorded in connection with blood tests in the course of a double-blind study in 41 patients suffering from chronic venous insufficiency of higher degrees of severity. They were treated in addition to compression measures
H E Knehr et al.
Arzneimittel-Forschung, 33(2), 211-214 (1983-01-01)
The influence of 2-ethyl-3-(4-hydroxy-benzoyl)-benzofurane (benzarone, Fragivic) on the energy metabolism of the wall of the rabbit common carotid artery and the rat portal vein was investigated by measuring the oxygen consumption of in vitro incubated vessel segments. Benzarone increased the
Effect of anti-inflammatory agents on the glycosaminoglycan metabolism in cultured human synovial cells.
K Kleesiek et al.
Rheumatology international, 2(4), 167-174 (1982-01-01)
Priska Kaufmann et al.
Hepatology (Baltimore, Md.), 41(4), 925-935 (2005-03-31)
Treatment with benzarone or benzbromarone can be associated with hepatic injury. Both drugs share structural similarities with amiodarone, a well-known mitochondrial toxin. Therefore, we investigated the hepatotoxicity of benzarone and benzbromarone as well as the analogues benzofuran and 2-butylbenzofuran. In
A Schmidt et al.
Arzneimittel-Forschung, 32(8), 810-815 (1982-01-01)
Rats of BD X strain and SHR/NIH Montreal Ingelheim strain (genetic hypertension) received a diet containing 3.9% cholesterol or 3.7% cholesterol plus 0.6% benzarone, respectively, and libitum for 5 or 9 months. The following chemical and ultrastructural results were obtained.
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