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Merck
CN

A9199

2-Amino-2-methyl-1-propanol

BioXtra, ≥95%

Synonym(s):

β-Aminoisobutyl alcohol, AMP

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About This Item

Linear Formula:
(CH3)2C(NH2)CH2OH
CAS Number:
124-68-5
Molecular Weight:
89.14
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
24891424
EC Number:
204-709-8
Beilstein/REAXYS Number:
505979
MDL number:
MFCD00008051

Key Documents

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cation traces

Ca: ≤0.0005%, Al: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

InChI

1S/C4H11NO/c1-4(2,5)3-6/h6H,3,5H2,1-2H3

InChI key

CBTVGIZVANVGBH-UHFFFAOYSA-N

SMILES string

CC(C)(N)CO

vapor density

3 (vs air)

vapor pressure

<1 mmHg ( 25 °C)

product line

BioXtra

assay

≥95%

form

liquid

impurities

≤0.005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

refractive index

n20/D 1.4455 (lit.)

pH

11.0-12 (25 °C, 8.9 g/L)

useful pH range

9.0-10.5

pKa (25 °C)

9.7

bp

165 °C (lit.)

mp

24-28 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

0.934 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

Quality Level

200

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Application

2-Amino-2-methyl-1-propanol has been used as an component in enzyme assay for screening the alkaline phosphatase activity in sarcoma osteogenic (SaOS-2) cells..

Biochem/physiol Actions

2-Amino-2-methyl-1-propanol is a substituted aliphatic alcohol and is used majorly as a pH balancer in cosmetic formulations. It has phototoxic effect as it can interact and penetrate above the sebum layer. However, it is not carcinogenic.

pictograms

Corrosion
GHS05

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

179.8 °F - closed cup

flash_point_c

82.1 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9705
MKCW4185
MKCS9480
MKCQ8028
MKCM9798

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The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro
Wang X, et al.
Biochemical Pharmacology, 102(6), 97-106 (2016)
Final amended report on safety assessment on aminomethyl propanol and aminomethyl propanediol
Burnett CL, et al.
International Journal of Toxicology, 28(6), 141S-161S (2009)
Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study
Hossy BH, et al.
Journal of Photochemistry and Photobiology. B, Biology, 173(6), 545-550 (2017)
Hidetaka Yamada et al.
The journal of physical chemistry. A, 115(14), 3079-3086 (2011-03-19)
We used density functional theory (DFT) calculations with the latest continuum solvation model (SMD/IEF-PCM) to determine the mechanism of CO(2) absorption into aqueous solutions of 2-amino-2-methyl-1-propanol (AMP). Possible absorption process reactions were investigated by transition-state optimization and intrinsic reaction coordinate
Muhammad Hasib-ur-Rahman et al.
Environmental science & technology, 46(20), 11443-11450 (2012-09-12)
One of the major drawbacks of aqueous alkanolamine based CO(2) capture processes is the requirement of significantly higher energy of regeneration. This weakness can be overcome by separating the CO(2)-captured product to regenerate the corresponding amine, thus avoiding the consumption
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