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A3168

Supelco

N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride

analytical standard, for drug analysis

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Synonym(s):
W-12
Empirical Formula (Hill Notation):
C14H18N2O2S · HCl
CAS Number:
89108-46-3
Molecular Weight:
314.83
MDL number:
MFCD00058052
UNSPSC Code:
41116107
PubChem Substance ID:
329770817
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

200

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

yellow

solubility

H2O: soluble (Stock solutions of approx. 5 mM are suggested. Stocks should be stable for at least 6 months when stored at 4 °C)

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].NCCCCNS(=O)(=O)c1ccc2ccccc2c1

InChI

1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H

InChI key

WYFVKUWCEVMLOL-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A calmodulin antagonist; inhibits Ca2+/calmodulin activated phosphodiesterase and myosin light chain kinase.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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American journal of physiology. Cell physiology, 296(4), C922-C929 (2009-01-23)
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Proceedings of the National Academy of Sciences of the United States of America, 78(7), 4354-4357 (1981-07-01)
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. Autoradiographic studies using tritiated W-7 showed that this compound penetrates the cell membrane, is distributed mainly in the cytoplasm, and inhibits proliferation
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