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A3168

Supelco

N-(4-Aminobutyl)-2-naphthalenesulfonamide hydrochloride

analytical standard, for drug analysis

Synonym(s):

W-12

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About This Item

Empirical Formula (Hill Notation):
C14H18N2O2S · HCl
CAS Number:
89108-46-3
Molecular Weight:
314.83
MDL number:
MFCD00058052
UNSPSC Code:
41116107
PubChem Substance ID:
329770817
NACRES:
NA.24

grade

analytical standard, for drug analysis

Quality Level

200

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

yellow

solubility

H2O: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].NCCCCNS(=O)(=O)c1ccc2ccccc2c1

InChI

1S/C14H18N2O2S.ClH/c15-9-3-4-10-16-19(17,18)14-8-7-12-5-1-2-6-13(12)11-14;/h1-2,5-8,11,16H,3-4,9-10,15H2;1H

InChI key

WYFVKUWCEVMLOL-UHFFFAOYSA-N

General description

Stock solutions of approx. 5 mM are suggested. Stocks should be stable for at least 6 months when stored at 4 °C

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A calmodulin antagonist; inhibits Ca2+/calmodulin activated phosphodiesterase and myosin light chain kinase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Proceedings of the National Academy of Sciences of the United States of America, 78(7), 4354-4357 (1981-07-01)
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and its derivatives are putative calmodulin antagonists that bind to calmodulin and inhibit Ca2+/calmodulin-regulated enzyme activities. Autoradiographic studies using tritiated W-7 showed that this compound penetrates the cell membrane, is distributed mainly in the cytoplasm, and inhibits proliferation
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