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A2428

Supelco

Amcinonide

analytical standard

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Empirical Formula (Hill Notation):
C28H35FO7
CAS Number:
51022-69-6
Molecular Weight:
502.57
EC Number:
256-915-2
MDL number:
MFCD00213379
UNSPSC Code:
41116107
PubChem Substance ID:
329770783

grade

analytical standard

Quality Level

400

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC6(CCCC6)O2)C(=O)COC(C)=O

InChI

1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1

InChI key

ILKJAFIWWBXGDU-MOGDOJJUSA-N

Gene Information

human ... NR3C1(2908)

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General description

Amcinonide is a highly potent topical corticosteroid. It possesses pharmacological properties like anti-pruritic, anti-inflammatory and vasoconstrictive activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

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Allergic contact dermatitis due to amcinonide.
R Hayakawa et al.
Contact dermatitis, 23(1), 49-50 (1990-07-01)
E M Koch et al.
Arzneimittel-Forschung, 36(10), 1540-1544 (1986-10-01)
The results of comparative studies with corticosteroid topicals on age-associated differences are presented. In each of the test series 10 to 14 subjects were included, either young adults aged 18-24 years or older adults aged 65-76 years. Tests on vasoconstriction
Contact dermatitis due to amcinonide.
E Sasaki et al.
Contact dermatitis, 18(1), 61-62 (1988-01-01)
R C Cornell
Cutis, 31(5), 566-569 (1983-05-01)
Thirty-nine patients with psoriasis were treated either with amcinonide ointment 0.1 percent twice a day or with fluocinonide ointment 0.05 percent three times a day in a two-week, randomized, parallel-group, double-blind study. The severities of the skin lesions at baseline
G Rivara et al.
Contact dermatitis, 21(2), 83-91 (1989-08-01)
22 cases of allergic contact dermatitis from topical corticosteroids were observed in Strasbourg and previously published. 7 further cases are reported here and the vehicle and concentration of corticosteroids for patch tests are discussed. A 0.1% concentration in petrolatum seemed
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