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A178

Supelco

Acetohexamide

analytical standard, ≥98% (HPLC)

Synonym(s):

4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C15H20N2O4S
CAS Number:
968-81-0
Molecular Weight:
324.40
EC Number:
213-530-4
MDL number:
MFCD00072156
UNSPSC Code:
41116107
PubChem Substance ID:
329770722

grade

analytical standard

Quality Level

100

Assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

DMSO: ~45 mg/mL
H2O: insoluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2

InChI

1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChI key

VGZSUPCWNCWDAN-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

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Application

Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Oral hypoglycemic agent

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD9331V
WXBD2738V
MKCL0143
MKCJ1550
MKCG3857

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Fluorimetric determination of acetohexamide in plasma and tablet formulations using 1-methylnicotinamide.
Girgis-Takla P and Chroneos I
Analyst, 104(1235), 117-123 (1979)
Zenghan Tong et al.
Journal of chromatography. A, 1218(49), 8915-8924 (2011-05-27)
This study examined the use of frontal analysis and high-performance affinity chromatography for detecting heterogeneous binding in biomolecular interactions, using the binding of acetohexamide with human serum albumin (HSA) as a model. It was found through the use of this
Yorishige Imamura et al.
Journal of applied toxicology : JAT, 24(6), 437-441 (2004-11-24)
This study was designed to elucidate strain- and sex-related differences of carbonyl reductase activity in rat kidney by using the oral antidiabetic drug acetohexamide as substrate. The frequency distribution of carbonyl reductase activities in kidney microsomes of male Fischer 344
Y Imamura et al.
Journal of biochemistry, 119(4), 648-652 (1996-04-01)
An enzyme catalyzing the metabolic reduction of acetohexamide [4-acetyl-N-(cyclohexyl-carbamoyl)benzenesulfonamide], an oral antidiabetic drug, was purified to homogeneity from the cytosolic fraction of rabbit heart. The molecular mass of the purified enzyme was estimated to be 110 kDa by gel filtration
H Takada et al.
The Journal of pharmacology and experimental therapeutics, 287(2), 504-507 (1998-11-10)
We examined the catalytic properties and physiological function of an enzyme responsible for the ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats. Progesterone, 17alpha-hydroxyprogesterone, cortisone and cortisol, which have a ketone group at 20-position
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