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A178

Supelco

Acetohexamide

analytical standard, ≥98% (HPLC)

Synonym(s):

4-Acetyl-N-[(cyclohexylamino)carbonyl]benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C15H20N2O4S
CAS Number:
968-81-0
Molecular Weight:
324.40
EC Number:
213-530-4
MDL number:
MFCD00072156
UNSPSC Code:
41116107
PubChem Substance ID:
329770722

grade

analytical standard

Quality Level

100

Assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

DMSO: ~45 mg/mL
H2O: insoluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2

InChI

1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

InChI key

VGZSUPCWNCWDAN-UHFFFAOYSA-N

Gene Information

human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)

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Application

Acetohexamide may be used as a reference standard for the determination of acetohexamide in presence of 1-methylnicotinamide reagent in plasma sample and tablet formulations by spectrofluorimetry method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Oral hypoglycemic agent

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBD9331V
WXBD2738V
MKCL0143
MKCJ1550
MKCG3857

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Hibah Aldawsari et al.
International journal of pharmaceutics, 453(2), 315-321 (2013-06-26)
A new polymorph of acetohexamide (Form VI) was prepared via the formation of a complex with 2-hydoxybutyl-β-cyclodextrin (HB-β-CD) in aqueous solution. An alkaline solution of acetohexamide and HB-β-CD was adjusted to pH 4.0 by titration with hydrochloric acid. The resulting
H Koyama et al.
Biopharmaceutics & drug disposition, 18(9), 791-801 (1998-01-16)
The binding properties of hypoglycaemic drugs to glycosylated human serum albumin (G-HSA) were investigated using a fluorescence quenching method. Displacement patterns between tolbutamide and Sudlow's-site-specific drugs to G-HSA were also investigated. The order of the binding affinities of these drugs
Hideaki Shimada et al.
Archives of toxicology, 76(1), 8-12 (2002-03-05)
Administration of cadmium (Cd) at a dose of 1.23 mg/kg (2.0 mg/kg as CdCl(2)) markedly decreased the activity of an enzyme (acetohexamide reductase) catalysing the ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of male rats. However, the
Yorishige Imamura et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 133(4), 587-592 (2002-11-30)
The pharmacokinetic profile of S(-)-hydroxyhexamide (S-HH), a pharmacologically active metabolite of acetohexamide, was examined in male and female rats. S-HH was eliminated more rapidly from plasma in the males than in the females. A significant sex difference was observed in
K Seri et al.
European journal of pharmacology, 389(2-3), 253-256 (2000-02-26)
We investigated the mechanism of the hypoglycemic effect of (R)-4-(1-acetoxyethyl)-N-(cyclohexylcarbamoyl)benzene-sulfonamide [(R)-acetoxyhexamide; (R)-ACX], a new sulfonylurea compound. (R)-ACX potently stimulated the release of insulin from cultured pancreatic beta-cells (HIT T15 cells), established from hamster islet cells SV40-transformed. When (R)-ACX was orally
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