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X114

Sigma-Aldrich

Triton™ X-114

laboratory grade

Synonym(s):

(1,1,3,3-Tetramethylbutyl)phenyl-polyethylene glycol, Polyethylene glycol tert-octylphenyl ether

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About This Item

Linear Formula:
(C2H4O)n C14H22O, n = 7 or 8
CAS Number:
9036-19-5
Beilstein:
2315025
MDL number:
MFCD00128254
UNSPSC Code:
12161900
PubChem Substance ID:
24902129
NACRES:
NA.21

grade

laboratory grade

Quality Level

200

description

non-ionic

mol wt

average mol wt 537

composition

t-Oct-C6H4-(OCH2CH2)xOH, x = 7-8

refractive index

n20/D 1.488 (lit.)

CMC

0.2 mM (20-25°C)

transition temp

pour point ~−9 °C
cloud point 23 °C

density

1.058 g/mL at 25 °C (lit.)

HLB

12.4

SMILES string

CC(C)(C)CC(C)(C)c1ccc(OCCOCCOCCOCCOCCOCCOCCO)cc1

InChI

1S/C28H50O8/c1-27(2,3)24-28(4,5)25-6-8-26(9-7-25)36-23-22-35-21-20-34-19-18-33-17-16-32-15-14-31-13-12-30-11-10-29/h6-9,29H,10-24H2,1-5H3

InChI key

HNLXNOZHXNSSPN-UHFFFAOYSA-N

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General description

Triton™ X-114 is a nonionic detergent. It is a good detergent for solubilizing membranes having reversible phase-separation property useful for the separation of intrinsic membrane proteins. Solution of Triton™ X-114 is homogeneous at 0°C but phase separation into aqueous phase and a detergent phase occurs above 20°C. Phase separation of proteins in solutions of Triton™ X-114 has been investigated. This octylphenol ethoxylate is compatible with anionic, cationic, and other nonionic surfactants and chemically stable in most acidic & alkaline solutions.

Application

Triton™ X-114 has been used:
  • To remove endotoxin from solutions of protein using phase separation technique
  • In the extraction and purification of DNA from endotoxin
  • In the biphasic extraction of lipoproteins from bacterial cell wall
  • As a non-ionic detergent with a low cloud point (23 °C) enabling protein solubilization with phase-partitioning of hydrophilic from amphiphilic proteins

Legal Information

Triton is a trademark of The Dow Chemical Company or an affiliated company of Dow

Signal Word

Danger

Hazard Statements

H302,H315,H318,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW6472
MKCV5666
MKCW4012
0000279694
0000273253

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Hartmann G and Krieg A M
Journal of Immunology, 164(2), 944-953 (2000)
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FEBS open bio, 7(9), 1338-1349 (2017-09-15)
Neuroglobin (Ngb) is a heme protein expressed in the vertebrate brain. We previously engineered a chimeric Ngb protein, in which module M1 of human Ngb is replaced by that of zebrafish Ngb, and showed that the chimeric ZHHH Ngb has
Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
Gehring A J, et al.
Journal of Immunology, 173(4), 2660-2668 (2004)
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Golenbock D T, et al.
Cellular Immunology, 258(1), 29-37 (2009)
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