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2,3,5,6-Tetramethylpyrazine

analytical standard

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Empirical Formula (Hill Notation):
C8H12N2
CAS Number:
1124-11-4
Molecular Weight:
136.19
Beilstein:
113100
EC Number:
214-391-2
MDL number:
MFCD00006146
UNSPSC Code:
85151701
PubChem Substance ID:
329770426
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥98.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

190 °C (lit.)

mp

77-80 °C (lit.)
85-87 °C

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

SMILES string

Cc1nc(C)c(C)nc1C

InChI

1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3

InChI key

FINHMKGKINIASC-UHFFFAOYSA-N

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General description

2,3,5,6-Tetramethylpyrazine is a flavor compound belonging to the class of pyrazines. It is found to be a main active ingredient of the traditional Chinese medicine, Chuanxiong and Ma-Huang herbs, used to treat asthma.

Application

2,3,5,6-Tetramethylpyrazine may be used as an analytical reference standard for the quantification of the analyte in Ephedrae herba and Ephedra sinica Stapf using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Analysis of tetramethylpyrazine in Ephedrae herba by gas chromatography?mass spectrometry and high-performance liquid chromatography
Lv K, et al.
Journal of Chromatography A, 878(1), 147-152 (2000)
Applications of Microbial Engineering (2013)
Separation and determination of ephedrine alkaloids and tetramethylpyrazine in ephedra sinica Stapf by gas chromatography-mass spectrometry
Journal of Chromatographic Science, 39(9), 370-374 (2001)
Shouliang Wang et al.
Drug design, development and therapy, 13, 1187-1196 (2019-05-23)
Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced neurotoxicity
Feng Zhang et al.
Toxicology and applied pharmacology, 265(1), 51-60 (2012-10-02)
Hepatic fibrosis represents a frequent event following chronic insult to trigger wound healing reactions with accumulation of extracellular matrix (ECM) in the liver. Activation of hepatic stellate cells (HSCs) is the pivotal event during liver fibrogenesis. Compelling evidence indicates that
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