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95054

Supelco

Azelaic acid

analytical standard

Synonym(s):

Nonanedioic acid

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About This Item

Linear Formula:
HO2C(CH2)7CO2H
CAS Number:
Molecular Weight:
188.22
Beilstein:
1101094
EC Number:
MDL number:
UNSPSC Code:
85151701
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor density

6.5 (vs air)

vapor pressure

<1 mmHg ( 20 °C)

Assay

≥98.5% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

bp

286 °C/100 mmHg (lit.)

mp

106-112 °C
109-111 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

format

neat

SMILES string

OC(=O)CCCCCCCC(O)=O

InChI

1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

InChI key

BDJRBEYXGGNYIS-UHFFFAOYSA-N

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General description

Azelaic acid (heptane-l,7-dicarboxylic acid), a dicarboxylic saturated acid, is an active component of some topical anti-acne preparations. It is reportedly identified in cosmetics and pharmaceuticals. Azelaic acid is found to suppress the growth of Propionibacterium spp. and reduce keratinization.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

Azelaic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Tobacco using gas chromatography coupled to mass spectrometry (GC-MS).
  • Topical preparations using reversed-phase liquid chromatographic (LC) with UV-Vis detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 1

Flash Point(F)

410.0 °F

Flash Point(C)

210 °C


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Certificates of Analysis (COA)

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Simultaneous determination of azelaic and benzoic acids in topical preparations by liquid chromatography
Mansour MA and Ibrahiem MM
Chromatographia, 55(7-8), 435-437 (2002)
Syntheses and QSAR studies of sorbic, cinnamic and ricinoleic acid derivatives as potential antibacterial agents
Narasimhan B, et al.
Indian Journal of Chemistry, 42B, 2828-2834 (2003)
Simultaneous determination of non?volatile, semi?volatile, and volatile organic acids in tobacco by SIM?Scan mode GC?MS
Wang B, et al.
Journal of Separation Science, 31(4), 721-726 (2008)
Dongdong Zhang et al.
Oxidative medicine and cellular longevity, 2020, 1295984-1295984 (2021-01-12)
Acute myeloid leukemia (AML) is a hematological malignancy with a poor prognosis attributed to elevated reactive oxygen species (ROS) levels. Thus, agents that inhibit ROS generation in AML should be exploited. Azelaic acid (AZA), a small molecular compound, can scavenge
Harald Gollnick et al.
Expert opinion on pharmacotherapy, 9(15), 2699-2706 (2008-09-23)
Rosacea represents a chronic inflammatory dermatosis of uncertain pathophysiology. There are several associated risk factors and the need for long-term treatment is well recognized. This diverse disease is frequently difficult to manage and has a significant impact on quality of

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