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94687

Supelco

Everolimus

analytical standard

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Synonym(s):
42-O-(2-Hydroxyethyl)rapamycin
Empirical Formula (Hill Notation):
C53H83NO14
CAS Number:
159351-69-6
Molecular Weight:
958.22
MDL number:
MFCD00929329
UNSPSC Code:
41116107
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥75.0% (qNMR)

shelf life

limited shelf life, expiry date on the label

application(s)

clinical testing

format

neat

storage temp.

−20°C

SMILES string

O=C(C([C@@]1(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C2=O)([H])O1)=O)N3[C@H](C(O[C@@]([C@@H](C[C@@]4([H])C[C@@H](OC)[C@H](OCCO)CC4)C)([H])CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)=O)CCCC3

InChI

1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChI key

HKVAMNSJSFKALM-GKUWKFKPSA-N

Gene Information

human ... FKBP1A(2280)

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General description

Everolimus (RAD001), a derivative of rapamycin, is commonly used as a drug for the inhibition of the mTOR pathway, affecting tumor cell division and angiogenesis.

Application

Everolimus may be used as a standard in the following clinical studies:
  • Investigation of its glucose-dependent growth-inhibitory property in breast cancer cell lines.
  • Evaluate its possible antiproliferative effects in human bronchial carcinoids in primary culture.

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Warning

Hazard Statements

H351,H361fd,H373,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 2 - STOT RE 2

Target Organs

Kidney,Testes

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells
Ariaans G, et al.
BMC Cancer, 17(1), 232-232 (2017)
Cardiac Electrophysiology: From Cell to Bedside, 17(1), 232-232 (2016)
Everolimus as a new potential antiproliferative agent in aggressive human bronchial carcinoids
Zatelli CM, et al.
Endocrine-Related Cancer, 17(3), 719-729 (2010)
Phosphorylation of 4E-BP1 predicts sensitivity to everolimus in gastric cancer cells
Nishi T, et al.
Cancer letters, 331(2), 220-229 (2013)

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