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94209

Supelco

Piperazine

analytical standard

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Synonym(s):
1,4-Diazacyclohexane, Diethylenediamine
Empirical Formula (Hill Notation):
C4H10N2
CAS Number:
110-85-0
Molecular Weight:
86.14
Beilstein:
102555
EC Number:
203-808-3
MDL number:
MFCD00005953
UNSPSC Code:
85151701
PubChem Substance ID:
329770313
NACRES:
NA.24

grade

analytical standard

Quality Level

100

vapor pressure

0.8 mmHg ( 20 °C)

Assay

≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

expl. lim.

14 %

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤3.0% water

bp

145-146 °C (lit.)

mp

109-112 °C (lit.)

solubility

H2O: 0.9 g/L at 20 °C

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
forensics and toxicology
personal care
veterinary

format

neat

SMILES string

C1CNCCN1

InChI

1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

InChI key

GLUUGHFHXGJENI-UHFFFAOYSA-N

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General description

Piperazine is an anthelmintic agent, which is used in the treatment of ascariasis and enterobiasis in mammals and birds.

Application

Piperazine may be used as a reference standard for the determination of piperazine in pharmaceutical drug formulations by hydrophilic interaction chromatography and evaporative light scattering detection method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Signal Word

Danger

Hazard Classifications

Eye Dam. 1 - Flam. Sol. 1 - Repr. 2 - Resp. Sens. 1B - Skin Corr. 1B - Skin Sens. 1B

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Novel method for the determination of piperazine in pharmaceutical drug substances using hydrophilic interaction chromatography and evaporative light scattering detection.
McClintic C, et al.
Journal of Liquid Chromatography and Related Technologies, 26(18), 3093-3104 (2003)
R A Lovell
The Veterinary clinics of North America. Small animal practice, 20(2), 453-468 (1990-03-01)
Review of all reports involving anthelmintics in dogs and cats to the IAPIC between January 1, 1986 and August 10, 1988, revealed that ivermectin (extra-label use) and piperazine accounted for over 50% of the calls assessed as toxicoses and suspected
Julio H K Rozenfeld et al.
Biochimica et biophysica acta, 1848(1 Pt A), 127-133 (2014-10-16)
In this work, the bilayer structure of novel cationic lipid diC16-amidine was compared to the one of zwitterionic dipalmitoyl phosphatidylcholine ( DPPC), which shares the same hydrophobic domain. Differential scanning calorimetry shows that DPPC and diC16-am idine bilayers have similar
Janie Sheridan et al.
Drug and alcohol review, 26(3), 335-343 (2007-04-25)
In this Harm Reduction Digest Sheridan, Butler, Wilkins and Russell address the emergent phenomenon of so-called 'legal party pills' which have become a significant drug issue in New Zealand and elsewhere. Although banned in a number of countries, they are
Rahul V Patel et al.
Mini reviews in medicinal chemistry, 13(11), 1579-1601 (2013-07-31)
This article purposes to provide insights to piperazine based molecular designs that will facilitate drug discovery program in future. In our pursuit to summarize the reservoir of bioactive agents, and in line with the synthetic economy of new heterocycles, many
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