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93049

Forskolin

analytical standard

Synonym(s):

7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin

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About This Item

Empirical Formula (Hill Notation):
C22H34O7
CAS Number:
66575-29-9
Molecular Weight:
410.50
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329770193
EC Number:
266-410-9
Beilstein/REAXYS Number:
1692716
MDL number:
MFCD00082317
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grade

analytical standard

Quality Level

100

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

SMILES string

CC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C

InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1

InChI key

OHCQJHSOBUTRHG-KGGHGJDLSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H312

Hazard Classifications

Acute Tox. 4 Dermal

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8828
BCCL9181
BCCK5587
BCCJ8482
BCCL0903

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T Marchetti et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 910-920 (2014-03-25)
Obstetric antiphospholipid syndrome (APS) is defined by pregnancy complications associated with antiphospholipid antibodies (aPL). The mechanisms of the pathogenic effects of aPL in pregnancy are poorly understood. Toll-like receptors (TLR) have been implicated previously in APS. The aims of our
Pietro G di Summa et al.
Neuroscience letters, 572, 26-31 (2014-05-06)
Collagen nerve guides are used clinically for peripheral nerve defects, but their use is generally limited to lesions up to 3 cm. In this study we combined collagen conduits with cells as an alternative strategy to support nerve regeneration over
Saulo J A Felizola et al.
Journal of molecular endocrinology, 52(2), 159-167 (2014-01-10)
Purkinje cell protein 4 (PCP4) is a calmodulin (CaM)-binding protein that accelerates calcium association and dissociation with CaM. It has been previously detected in aldosterone-producing adenomas (APA), but details on its expression and function in adrenocortical tissues have remained unknown.
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Global Trade Item Number

SKUGTIN
07499-50MG04061834242901
W470411-SAMPLE-K04061841851981
W470411-1KG-K04061841851967
W470411-100G-K04061841851950
PHR2525-100MG04061842552351
148245-100G04061838737922
93049-10MG04061833272589