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1-(Trimethylsilyl)imidazole - Pyridine mixture

for GC derivatization, LiChropur™

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Synonym(s):
Silylating mixture VII, TMSI+Pyridine
CAS Number:
8077-35-8
MDL number:
MFCD00284770
UNSPSC Code:
12000000
eCl@ss:
39151701
PubChem Substance ID:
329770159
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

description

1:4 (v/v)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

density

0.98 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

c1ccncc1.C[Si](C)(C)n2ccnc2

InChI

1S/C6H12N2Si.C5H5N/c1-9(2,3)8-5-4-7-6-8;1-2-4-6-5-3-1/h4-6H,1-3H3;1-5H

InChI key

PFVKFOIOKNIZKY-UHFFFAOYSA-N

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General description

1-(Trimethylsilyl)imidazole-Pyridine mixture is useful for derivatizing wet sugar samples, hindered hydroxyl groups in steroids and, in conjunction with fluorinated acylation reagents, amino acids. For moderately hindered or slowly reacting compounds, pyridine is an especially useful solvent for TMSI because of its ability to act as an HCl acceptor in silylation reactions involving organochlorosilanes.

Application

Learn more in the Product Information

Other Notes

Silylating mixture for the mild silylation of alcohols. It is often called Tri-Sil Z

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

62.6 °F

Flash Point(C)

17 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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G. Van Ling
Journal of Chromatography A, 44, 175-175 (1969)
M A Andrews
Carbohydrate research, 194, 1-19 (1989-12-01)
Two new procedures for the gas-chromatographic analysis of monosaccharides are reported. One involves derivatization of the sugars by reaction with O-benzylhydroxylamine followed by trifluoroacetylation with N-methylbis(trifluoroacetamide) and chromatography on a DB-1701 capillary column. This technique probably provides the best resolution

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