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917893

Sigma-Aldrich

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

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Synonym(s):
Semi-flexible linker for PROTAC® development
Empirical Formula (Hill Notation):
C12H18ClNO
CAS Number:
371981-27-0
Molecular Weight:
227.73
MDL number:
MFCD29075591
UNSPSC Code:
12352116

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

hydroxyl

storage temp.

2-8°C

SMILES string

OCC1=C(C2CCNCC2)C=CC=C1.Cl

Application

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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